Platelet factor 4

BE0001129ProteinHumansPF4

Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation (PubMed:29930254, PubMed:9531587). It is acted on by 4 drugs in DrugBank.

Gene name
PF4
UniProtKB entry
P02776Swiss-Prot
Cellular location
Secreted
Residues / weight
101 residues · 10,845 Da
Also known as
C-X-C motif chemokine 4 · CXCL4 · Iroplact · Oncostatin-A · PF-4

Resolves to

Protein
UniProtP02776UniProt namePLF4_HUMAN
Gene
HGNCHGNC:8861NCBI Gene5196GenBank189851GeneCardsPF4
Pharmacology
KEGGhsa:5196
Structure
PDB1DN3PDB1F9QPDB1F9R
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Platelet factor 4, how selective are they, and which programs against it are still in active trials?

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