Amino acid transporter heavy chain SLC3A1

BE0001130ProteinHumansSLC3A1

Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane (By similarity) (PubMed:10588648, PubMed:11318953, PubMed:16609684, PubMed:16825196, PubMed:32494597, PubMed:32817565, PubMed:7686906, PubMed:8486766, PubMed:8663184, PubMed:8663357). It is acted on by 1 drug in DrugBank.

Gene name
SLC3A1
UniProtKB entry
Q07837Swiss-Prot
Cellular location
Cell membrane
Residues / weight
685 residues · 78,851 Da
Also known as
b(0,+)-type amino acid transporter-related heavy chain · D2h · NBAT · Neutral and basic amino acid transport protein · rBAT

Resolves to

Protein
UniProtQ07837UniProt nameSLC31_HUMAN
Gene
HGNCHGNC:11025NCBI Gene6519GenBank306442GeneCardsSLC3A1
Pharmacology
KEGGhsa:6519
Structure
PDB6LI9PDB6LIDPDB6YUP
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Amino acid transporter heavy chain SLC3A1, how selective are they, and which programs against it are still in active trials?

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