ATP-sensitive inward rectifier potassium channel 12

BE0001131ProteinHumansKCNJ12

Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. It is acted on by 1 drug in DrugBank.

Gene name
KCNJ12
UniProtKB entry
Q14500Swiss-Prot
Cellular location
Membrane
Residues / weight
433 residues · 49,001 Da
Also known as
Inward rectifier K(+) channel Kir2.2 · Inward rectifier K(+) channel Kir2.2v · IRK-2 · IRK2 · KCNJN1

Resolves to

Protein
UniProtQ14500UniProt nameKCJ12_HUMAN
Gene
HGNCHGNC:6258NCBI Gene3768GenBank567019GeneCardsKCNJ12
Pharmacology
IUPHAR/GtoPdb431KEGGhsa:3768
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-sensitive inward rectifier potassium channel 12, how selective are they, and which programs against it are still in active trials?

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