Dofetilide is a class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. A drug used to treat an irregular heartbeat.
- Mechanism
- Curator reviewed
The mechanism of action of Dofetilide is a blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium current, IKr. This inhibition of potassium channels results in a prolongation of action potential duration and the effective refractory period of accessory pathways (both anterograde and retrograde conduction in the accessory pathway).
- Primary indication
- For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal...Curator reviewed · 4 structured indications
- Formula / weight
- C19H27N3O5S2 · 441.565 g/mol (avg)
- First approval
- United States, 1999
- Code names
- UK-68,798
- Brand names
Resolves to
IXTMWRCNAAVVAI-UHFFFAOYSA-NSMILESCN(CCOC1=CC=C(NS(C)(=O)=O)C=C1)CCC1=CC=C(NS(C)(=O)=O)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Dofetilide, and which of those have an active Phase 3 trial?
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