Vitamin D-binding protein

BE0001141ProteinHumansGC

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. It is acted on by 8 drugs in DrugBank.

Gene name
GC
UniProtKB entry
P02774Swiss-Prot
Cellular location
Secreted
Residues / weight
474 residues · 52,917 Da
Also known as
DBP · DBP-maf · Gc · Gc protein-derived macrophage activating factor · Gc-globulin

Resolves to

Protein
UniProtP02774UniProt nameVTDB_HUMAN
Gene
HGNCHGNC:4187NCBI Gene2638GenBank639896GeneCardsGC
Pharmacology
KEGGhsa:2638
Structure
PDB1J78PDB1J7EPDB1KW2
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Vitamin D-binding protein, how selective are they, and which programs against it are still in active trials?

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