Protein-L-isoaspartate(D-aspartate) O-methyltransferase

BE0001144ProteinHumansPCMT1

Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). It is acted on by 2 drugs in DrugBank.

Gene name
PCMT1
UniProtKB entry
P22061Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
227 residues · 24,636 Da
Also known as
2.1.1.77 · L-isoaspartyl protein carboxyl methyltransferase · PIMT · Protein L-isoaspartyl/D-aspartyl methyltransferase · Protein-beta-aspartate methyltransferase

Resolves to

Protein
UniProtP22061UniProt namePIMT_HUMAN
Gene
HGNCHGNC:8728NCBI Gene5110GenBank180637GeneCardsPCMT1
Pharmacology
KEGGhsa:5110
Structure
PDB1I1NPDB1KR5
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Protein-L-isoaspartate(D-aspartate) O-methyltransferase, and which indications are they being tested in?

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