Inositol monophosphatase 1

BE0001152ProteinHumansIMPA1

Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol (PubMed:17068342, PubMed:8718889, PubMed:9462881). It is acted on by 5 drugs in DrugBank.

Gene name
IMPA1
UniProtKB entry
P29218Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
277 residues · 30,189 Da
Also known as
3.1.3.25 · D-galactose 1-phosphate phosphatase · IMP 1 · IMPA · IMPase 1

Resolves to

Protein
UniProtP29218UniProt nameIMPA1_HUMAN
Gene
HGNCHGNC:6050NCBI Gene3612GenBank395340GeneCardsIMPA1
Pharmacology
IUPHAR/GtoPdb1463KEGGhsa:3612
Structure
PDB1AWBPDB1IMAPDB1IMB
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inositol monophosphatase 1, how selective are they, and which programs against it are still in active trials?

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