Beta-hexosaminidase subunit beta

BE0001153ProteinHumansHEXB

Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:8123671, PubMed:8672428, PubMed:9694901). It is acted on by 5 drugs in DrugBank.

Gene name
HEXB
UniProtKB entry
P07686Swiss-Prot
Cellular location
Lysosome
Residues / weight
556 residues · 63,137 Da
Also known as
3.2.1.52 · Beta-N-acetylhexosaminidase subunit beta · Cervical cancer proto-oncogene 7 protein · HCC-7 · Hexosaminidase subunit B

Resolves to

Protein
UniProtP07686UniProt nameHEXB_HUMAN
Gene
HGNCHGNC:4879NCBI Gene3074GenBank179462GeneCardsHEXB
Pharmacology
KEGGhsa:3074
Structure
PDB1NOUPDB1NOWPDB1NP0
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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17GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beta-hexosaminidase subunit beta, how selective are they, and which programs against it are still in active trials?

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