Hematopoietic prostaglandin D synthase

BE0001167ProteinHumansHPGDS

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of... It is acted on by 17 drugs in DrugBank.

Gene name
HPGDS
UniProtKB entry
O60760Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
199 residues · 23,344 Da
Also known as
5.3.99.2 · Glutathione S-transferase · Glutathione-dependent PGD synthase · Glutathione-requiring prostaglandin D synthase · GST class-sigma

Resolves to

Protein
UniProtO60760UniProt nameHPGDS_HUMAN
Gene
HGNCHGNC:17890NCBI Gene27306GenBank3046817GeneCardsHPGDS
Pharmacology
IUPHAR/GtoPdb1381KEGGhsa:27306
Structure
PDB1IYHPDB1IYIPDB1V40
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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51+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hematopoietic prostaglandin D synthase, how selective are they, and which programs against it are still in active trials?

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