Sucrase-isomaltase, intestinal

BE0001176ProteinHumansSI

Bifunctional enzyme with both sucrase and isomaltase activities involved in breakdown of dietary starch oligosaccharides in small intestine. It is acted on by 9 drugs in DrugBank.

Gene name
SI
UniProtKB entry
P14410Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
1,827 residues · 209,451 Da

Resolves to

Protein
UniProtP14410UniProt nameSUIS_HUMAN
Gene
HGNCHGNC:10856NCBI Gene6476GenBank36645GeneCardsSI
Pharmacology
KEGGhsa:6476
Structure
PDB3LPOPDB3LPP
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sucrase-isomaltase, intestinal, how selective are they, and which programs against it are still in active trials?

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