Transforming protein RhoA

BE0001190ProteinHumansRHOA

Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. It is acted on by 3 drugs in DrugBank.

Gene name
RHOA
UniProtKB entry
P61586Swiss-Prot
Cellular location
Cell membrane
Residues / weight
193 residues · 21,768 Da
Also known as
3.6.5.2 · ARH12 · ARHA · h12 · Rho cDNA clone 12

Resolves to

Protein
UniProtP61586UniProt nameRHOA_HUMAN
Gene
HGNCHGNC:667NCBI Gene387GenBank36030GeneCardsRHOA
Pharmacology
KEGGhsa:387
Structure
PDB1A2BPDB1CC0PDB1CXZ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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37GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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54+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transforming protein RhoA, how selective are they, and which programs against it are still in active trials?

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