Steryl-sulfatase

BE0001197ProteinHumansSTS

Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. It is acted on by 10 drugs in DrugBank.

Gene name
STS
UniProtKB entry
P08842Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle, microneme membrane
Residues / weight
583 residues · 65,492 Da
Also known as
3.1.6.2 · ARSC1 · Arylsulfatase C · ASC · Estrone sulfatase

Resolves to

Protein
UniProtP08842UniProt nameSTS_HUMAN
Gene
HGNCHGNC:11425NCBI Gene412GenBank338565GeneCardsSTS
Pharmacology
KEGGhsa:412
Structure
PDB1P49PDB8EG3
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Steryl-sulfatase, how selective are they, and which programs against it are still in active trials?

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