Glucose-6-phosphate isomerase

BE0001199ProteinHumansGPI

Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:28803808). It is acted on by 12 drugs in DrugBank.

Gene name
GPI
UniProtKB entry
P06744Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
558 residues · 63,147 Da
Also known as
5.3.1.9 · AMF · Autocrine motility factor · D-hexose-6-phosphate anomerase · Glucose-6-phosphate C2-epimerase

Resolves to

Protein
UniProtP06744UniProt nameG6PI_HUMAN
Gene
HGNCHGNC:4458NCBI Gene2821GenBank189238GeneCardsGPI
Pharmacology
KEGGhsa:2821
Structure
PDB1IATPDB1IRIPDB1JIQ
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glucose-6-phosphate isomerase, how selective are they, and which programs against it are still in active trials?

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