Interleukin-5

BE0001208ProteinHumansIL5

Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). It is acted on by 5 drugs in DrugBank.

Gene name
IL5
UniProtKB entry
P05113Swiss-Prot
Cellular location
Secreted
Residues / weight
134 residues · 15,238 Da
Also known as
B-cell differentiation factor I · Eosinophil differentiation factor · IL-5 · T-cell replacing factor · TRF

Resolves to

Protein
UniProtP05113UniProt nameIL5_HUMAN
Gene
HGNCHGNC:6016NCBI Gene3567GenBank33836GeneCardsIL5
Pharmacology
KEGGhsa:3567
Structure
PDB1HULPDB3QT2PDB3VA2
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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12Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-5, how selective are they, and which programs against it are still in active trials?

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