Metallo-beta-lactamase type 2

BE0001212ProteinBacteroides fragilisccrA

Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. It is acted on by 2 drugs in DrugBank.

Gene name
ccrA
UniProtKB entry
P25910Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
249 residues · 27,257 Da
Also known as
3.5.2.6 · B2 metallo-beta-lactamase · Beta-lactamase II · Beta-lactamase type II · Carbapenem and cephamycin resistance

Resolves to

Protein
UniProtP25910UniProt nameBLAB_BACFG
Gene
GenBank143932
Structure
PDB1A7TPDB1A8TPDB1HLK
Drugs

What you can answer from here — as of May 03, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Metallo-beta-lactamase type 2, how selective are they, and which programs against it are still in active trials?

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