Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

BE0001229ProteinSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)cobT

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) (PubMed:10587435, PubMed:11441022, PubMed:24121107, PubMed:8206834, Ref.7). It is acted on by 24 drugs in DrugBank.

Gene name
cobT
UniProtKB entry
Q05603Swiss-Prot
Residues / weight
356 residues · 36,612 Da
Also known as
2.4.2.21 · N(1)-alpha-phosphoribosyltransferase · NN:DBI PRT

Resolves to

Protein
UniProtQ05603UniProt nameCOBT_SALTY
Gene
NCBI Gene1253537GenBank535767
Pharmacology
KEGGstm:STM2016
Structure
PDB1D0SPDB1D0VPDB1JH8
Drugs

What you can answer from here — as of September 07, 2019

24DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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52+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, how selective are they, and which programs against it are still in active trials?

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