2-dehydro-3-deoxyphosphooctonate aldolase

Details

Name
2-dehydro-3-deoxyphosphooctonate aldolase
Kind
protein
Synonyms
  • 2.5.1.55
  • 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
  • KDO 8-P synthase
  • KDO-8-phosphate synthase
  • KDOPS
  • Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene Name
kdsA
UniProtKB Entry
O66496Swiss-Prot
Organism
Aquifex aeolicus (strain VF5)
NCBI Taxonomy ID
224324
Amino acid sequence
>lcl|BSEQ0010875|2-dehydro-3-deoxyphosphooctonate aldolase
MEKFLVIAGPCAIESEELLLKVGEEIKRLSEKFKEVEFVFKSSFDKANRSSIHSFRGHGL
EYGVKALRKVKEEFGLKITTDIHESWQAEPVAEVADIIQIPAFLCRQTDLLLAAAKTGRA
VNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLTERGTTFGYNNLVVDFRSLPIMKQWAKVI
YDATHSVQLPGGLGDKSGGMREFIFPLIRAAVAVGCDGVFMETHPEPEKALSDASTQLPL
SQLEGIIEAILEIREVASKYYETIPVK
Number of residues
267
Molecular Weight
29734.17
Theoretical pI
6.68
GO Classification
Functions
3-deoxy-8-phosphooctulonate synthase activity
Processes
keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
Components
cytoplasm
General Function
3-deoxy-8-phosphooctulonate synthase activity
Specific Function
Not Available
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010876|2-dehydro-3-deoxyphosphooctonate aldolase (kdsA)
ATGGAAAAGTTTTTAGTGATAGCTGGACCCTGCGCGATAGAGAGCGAGGAACTTCTCCTA
AAGGTAGGGGAGGAGATAAAGCGTTTATCGGAGAAGTTCAAAGAAGTTGAGTTCGTATTT
AAGTCTTCCTTTGATAAAGCGAACCGCTCCTCAATACATTCCTTCAGGGGGCACGGTCTT
GAATACGGGGTAAAGGCTCTGAGGAAGGTAAAGGAAGAGTTCGGACTGAAGATTACCACG
GATATTCACGAGAGCTGGCAAGCTGAACCAGTTGCAGAAGTTGCGGACATAATCCAGATA
CCTGCCTTTTTATGCAGGCAGACTGACCTCCTCCTTGCGGCTGCAAAAACGGGAAGGGCT
GTAAACGTGAAGAAGGGTCAGTTTTTAGCCCCTTGGGACACGAAGAACGTGGTTGAAAAA
TTAAAGTTCGGCGGTGCTAAGGAGATATACCTCACGGAGAGAGGAACTACCTTCGGATAC
AACAACCTCGTTGTAGATTTCAGGAGCCTACCCATAATGAAACAGTGGGCAAAGGTTATA
TACGACGCCACCCACAGCGTCCAGCTCCCCGGAGGTCTCGGGGACAAATCAGGAGGAATG
AGGGAGTTTATATTCCCCTTAATCCGTGCTGCGGTTGCGGTAGGTTGTGACGGTGTGTTT
ATGGAAACACACCCAGAACCAGAAAAGGCACTCTCGGACGCATCAACTCAGCTTCCCCTC
TCCCAGCTGGAAGGGATAATAGAGGCTATCCTTGAGATAAGGGAAGTGGCTTCAAAGTAT
TACGAAACAATTCCCGTTAAATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO66496
UniProtKB Entry NameKDSA_AQUAE
GenBank Protein ID2982835
GenBank Gene IDAE000657
PDB ID(s)1FWN, 1FWS, 1FWT, 1FWW, 1FX6, 1FXP, 1FXQ, 1FY6, 1JCX, 1JCY, 1LRN, 1LRO, 1LRQ, 1PCK, 1PCW, 1PE1, 1T8X, 1T96, 1T99, 1ZHA, 1ZJI, 2A21, 2A2I, 2EF9, 2NWR, 2NWS, 2NX1, 2NX3, 2NXG, 2NXH, 2NXI, 3E0I, 3E12
KEGG IDaae:aq_085
NCBI Gene ID1192509
General References
  1. Deckert G, Warren PV, Gaasterland T, Young WG, Lenox AL, Graham DE, Overbeek R, Snead MA, Keller M, Aujay M, Huber R, Feldman RA, Short JM, Olsen GJ, Swanson RV: The complete genome of the hyperthermophilic bacterium Aquifex aeolicus. Nature. 1998 Mar 26;392(6674):353-8. [Article]
  2. Duewel HS, Sheflyan GY, Woodard RW: Functional and biochemical characterization of a recombinant 3-Deoxy-D-manno-octulosonic acid 8-phosphate synthase from the hyperthermophilic bacterium Aquifex aeolicus. Biochem Biophys Res Commun. 1999 Sep 24;263(2):346-51. [Article]
  3. Wang J, Duewel HS, Stuckey JA, Woodard RW, Gatti DL: Function of His185 in Aquifex aeolicus 3-deoxy-D-manno-octulosonate 8-phosphate synthase. J Mol Biol. 2002 Nov 22;324(2):205-14. [Article]

Associated Data

Drug Relations
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1-Deoxy-6-O-Phosphono-1-[(Phosphonomethyl)Amino]-L-Threo-HexitolexperimentalunknowntargetDetails
2-(Phosphonooxy)Butanoic AcidexperimentalunknowntargetDetails
Arabinose-5-phosphateexperimentalunknowntargetDetails
D-erythrose 4-phosphateexperimentalunknowntargetDetails