Ribose-5-phosphate
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Overview
- DrugBank ID
- DB02053
- Type
- Small Molecule
- Clinical Trials
- Phase 0
- 0
- Phase 1
- 0
- Phase 2
- 0
- Phase 3
- 0
- Phase 4
- 0
Identification
- Generic Name
- Ribose-5-phosphate
- DrugBank Accession Number
- DB02053
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 230.1098
Monoisotopic: 230.01915384 - Chemical Formula
- C5H11O8P
- Synonyms
- 5-O-phosphono-D-ribose
- aldehydo-D-ribose 5-phosphate
- D-Ribose 5-phosphate
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism URibose-5-phosphate isomerase A Not Available Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) U2-dehydro-3-deoxyphosphooctonate aldolase Not Available Aquifex aeolicus (strain VF5) UADP-ribose pyrophosphatase Not Available Thermus thermophilus - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups.
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Carbohydrates and carbohydrate conjugates
- Direct Parent
- Pentose phosphates
- Alternative Parents
- Monosaccharide phosphates / Monoalkyl phosphates / Beta-hydroxy aldehydes / Alpha-hydroxyaldehydes / Secondary alcohols / Polyols / Organic oxides / Hydrocarbon derivatives
- Substituents
- Alcohol / Aldehyde / Aliphatic acyclic compound / Alkyl phosphate / Alpha-hydroxyaldehyde / Beta-hydroxy aldehyde / Carbonyl group / Hydrocarbon derivative / Monoalkyl phosphate / Monosaccharide phosphate
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- D-ribose 5-phosphate (CHEBI:17797)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 4B2428FLTO
- CAS number
- 4151-19-3
- InChI Key
- PPQRONHOSHZGFQ-LMVFSUKVSA-N
- InChI
- InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h1,3-5,7-9H,2H2,(H2,10,11,12)/t3-,4+,5-/m0/s1
- IUPAC Name
- {[(2R,3R,4R)-2,3,4-trihydroxy-5-oxopentyl]oxy}phosphonic acid
- SMILES
- [H][C@@](O)(COP(O)(O)=O)[C@@]([H])(O)[C@@]([H])(O)C=O
References
- General References
- Not Available
- External Links
- KEGG Compound
- C00117
- PubChem Compound
- 77982
- PubChem Substance
- 46507722
- ChemSpider
- 70368
- ChEBI
- 17797
- ZINC
- ZINC000022116391
- PDBe Ligand
- R52
- Wikipedia
- Ribose_5-phosphate
- PDB Entries
- 1jcy / 1u9z / 1v8t / 1zha / 1zji / 2r5n / 2vvp / 3hee / 3m6l / 3uw1 … show 7 more
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 19.3 mg/mL ALOGPS logP -1.6 ALOGPS logP -3.1 Chemaxon logS -1.1 ALOGPS pKa (Strongest Acidic) 1.49 Chemaxon pKa (Strongest Basic) -3.5 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 144.52 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 42.26 m3·mol-1 Chemaxon Polarizability 17.78 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 134.89224 predictedDeepCCS 1.0 (2019) [M+H]+ 137.28781 predictedDeepCCS 1.0 (2019) [M+Na]+ 144.53273 predictedDeepCCS 1.0 (2019)
Targets
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1. DetailsRibose-5-phosphate isomerase A
- Kind
- Protein
- Organism
- Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
- Pharmacological action
- Unknown
- General Function
- Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
- Specific Function
- ribose-5-phosphate isomerase activity
- Gene Name
- rpiA
- Uniprot ID
- Q5SIR5
- Uniprot Name
- Ribose-5-phosphate isomerase A
- Molecular Weight
- 24066.72 Da
References
- Kind
- Protein
- Organism
- Aquifex aeolicus (strain VF5)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- 3-deoxy-8-phosphooctulonate synthase activity
- Gene Name
- kdsA
- Uniprot ID
- O66496
- Uniprot Name
- 2-dehydro-3-deoxyphosphooctonate aldolase
- Molecular Weight
- 29734.17 Da
References
3. DetailsADP-ribose pyrophosphatase
- Kind
- Protein
- Organism
- Thermus thermophilus
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- ADP-sugar diphosphatase activity
- Gene Name
- ndx4
- Uniprot ID
- Q84CU3
- Uniprot Name
- ADP-ribose pyrophosphatase
- Molecular Weight
- 19263.785 Da
Drug created at June 13, 2005 13:24 / Updated at June 12, 2020 16:52