Botulinum neurotoxin type B

BE0001263ProteinClostridium botulinumbotB

Botulinum neurotoxin type B Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory... It is acted on by 5 drugs in DrugBank.

Gene name
botB
UniProtKB entry
P10844Swiss-Prot
Cellular location
Secreted
Residues / weight
1,291 residues · 150,801 Da
Also known as
3.4.24.69 · BoNT/B · Bontoxilysin-B

Resolves to

Protein
UniProtP10844UniProt nameBXB_CLOBO
Gene
GenBank144735
Structure
PDB1EPWPDB1F31PDB1F82
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Botulinum neurotoxin type B, how selective are they, and which programs against it are still in active trials?

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