NAV

Beta-D-Glucose

Targets (91)Enzymes (1)

Identification

Name
Beta-D-Glucose
Accession Number
DB02379
Description

A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.

Type
Small Molecule
Groups
Experimental
Structure
Thumb
3D
Similar Structures
Weight
Average: 180.1559
Monoisotopic: 180.063388116
Chemical Formula
C6H12O6
Synonyms
  • beta-D-glucopyranose
  • Beta-D-glucose anhydrous
  • Beta-D-glucose, anhydrous
  • Glucoside
  • β-D-glucose

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UGlycogen phosphorylase, muscle formNot AvailableHumans
UXylose isomeraseNot AvailableStreptomyces olivochromogenes
UGlucokinaseNot AvailableHumans
UFerrichrome-iron receptorNot AvailableEscherichia coli (strain K12)
UAldose 1-epimeraseNot AvailableLactococcus lactis
UPossible cellulase CelA1 (Endoglucanase) (Endo-1,4-beta-glucanase) (FI-cmcase) (Carboxymethyl cellulase)Not AvailableMycobacterium tuberculosis
UGlucokinaseNot AvailableEscherichia coli (strain K12)
UAmylaseNot AvailableBacillus sp.
UFucose-binding lectin PA-IILNot AvailablePseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
UBH0236 proteinNot AvailableBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
ULaminarinaseNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UEndo-1,4-beta-xylanase ANot AvailableClostridium stercorarium
UCellulase BNot AvailableCellvibrio mixtus
UEndoglucanase CNot AvailableCellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547)
UCellulose 1,4-beta-cellobiosidase (reducing end) CelSNot AvailableClostridium thermocellum
UD-galactose-binding periplasmic proteinNot AvailableEscherichia coli (strain K12)
UGlycosyltransferase 6 domain-containing protein 1Not AvailableHumans
UGlucosamine-6-phosphate isomerase 1Not AvailableHumans
UBeta-amylaseNot AvailableBacillus cereus
UADP-ribose pyrophosphatase, mitochondrialNot AvailableHumans
USWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5Not AvailableHumans
UCyclomaltodextrin glucanotransferaseNot AvailableThermoanaerobacter thermosulfurogenes
UEnterotoxin type BNot AvailableStaphylococcus aureus
UAlpha-amylase 1Not AvailableHumans
UMaltodextrin phosphorylaseNot AvailableEscherichia coli (strain K12)
UShiga-like toxin 1 subunit BNot AvailableBacteriophage H30
UNeurocan core proteinNot AvailableHumans
UBeta-glucanaseNot AvailablePaenibacillus macerans
UQuinoprotein glucose dehydrogenase BNot AvailableAcinetobacter calcoaceticus
UAlpha-amylaseNot AvailableBacillus amyloliquefaciens
UDNANot AvailableHumans
UAlpha-amylaseNot AvailablePseudoalteromonas haloplanktis
UCellulase BNot AvailableStreptomyces lividans
UChondroitinase-BNot AvailablePedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)
UAspartate ammonia-lyaseNot AvailableEscherichia coli (strain K12)
UEndoglucanase 5ANot AvailableBacillus agaradhaerens
ULactase-like proteinNot AvailableHumans
UAmylosucraseNot AvailableNeisseria polysaccharea
UPancreatic alpha-amylaseNot AvailableHumans
UPutative monooxygenase MoxCNot AvailableBacillus subtilis (strain 168)
UEndoglucanase E1Not AvailableAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
UD-galactose-binding periplasmic proteinNot AvailableSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
UEcotinNot AvailableEscherichia coli (strain K12)
UA/G-specific adenine glycosylaseNot AvailableEscherichia coli (strain K12)
UKeratin-associated protein 5-2Not AvailableHumans
USialoadhesinNot AvailableHumans
UNeopullulanaseNot AvailableGeobacillus stearothermophilus
UEndo-1,4-beta-xylanase ANot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UMaltoporinNot AvailableSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
UHexokinaseNot AvailableBlood fluke
UNeopullulanase 1Not AvailableThermoactinomyces vulgaris
UEndo-1,4-beta-xylanaseNot AvailableGeobacillus stearothermophilus
UCyclomaltodextrin glucanotransferaseNot AvailableBacillus circulans
UMaltoporinNot AvailableEscherichia coli (strain K12)
UMyoglobinNot AvailableHumans
UGalectin-2Not AvailableHumans
UProstaglandin G/H synthase 1Not AvailableHumans
UHexokinase-1Not AvailableHumans
UMalto-oligosyltrehalose trehalohydrolaseNot AvailableDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
UAlpha-amylaseNot AvailableBacillus subtilis (strain 168)
UInorganic polyphosphate/ATP-glucomannokinaseNot AvailableArthrobacter sp. (strain KM)
UExoglucanase/xylanaseNot AvailableCellulomonas fimi
UDiacetyl reductase [(S)-acetoin forming]Not AvailableKlebsiella pneumoniae
UCyclomaltodextrin glucanotransferaseNot AvailableBacillus sp. (strain 1011)
UCapsid protein VP1Not AvailableMPyV
UEndoglucanase GNot AvailableClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
UHydrolaseNot AvailableStreptomyces olivaceoviridis
UGalectin-7Not AvailableHumans
UCholera enterotoxin subunit BNot AvailableVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
UKeratin-associated protein 5-3Not AvailableHumans
UDimethyl sulfoxide/trimethylamine N-oxide reductaseNot AvailableRhodobacter sphaeroides
UEndoglucanase C307Not AvailableClostridium sp. (strain F1)
UAlpha-amylase 2BNot AvailableHumans
UEndo-1,4-beta glucanase EngFNot AvailableClostridium cellulovorans
UNeopullulanase 2Not AvailableThermoactinomyces vulgaris
UEndoglucanase E-4Not AvailableThermomonospora fusca
UBotulinum neurotoxin type BNot AvailableClostridium botulinum
UOrf proteinNot AvailableEscherichia coli
UTetanus toxinNot AvailableClostridium tetani (strain Massachusetts / E88)
UXylose isomeraseNot AvailableStreptomyces rubiginosus
UGlucan 1,4-alpha-maltohexaosidaseNot AvailableBacillus sp. (strain 707)
UGlucan 1,4-alpha-maltotetraohydrolaseNot AvailablePseudomonas stutzeri
UEndoglucanase FNot AvailableClostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
UGlucose--fructose oxidoreductaseNot AvailableZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
UBifunctional tail proteinNot AvailableEnterobacteria phage P22
UGlycogen phosphorylase, liver formNot AvailableHumans
UPulmonary surfactant-associated protein DNot AvailableHumans
UInterferon betaNot AvailableHumans
UMaltose-binding periplasmic proteinNot AvailableEscherichia coli (strain K12)
UEnoyl-[acyl-carrier-protein] reductase [NADH] FabINot AvailableEscherichia coli (strain K12)
UEndoglucanase ANot AvailableClostridium thermocellum
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Categories

Drug Categories
Not Available
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
Hexoses
Alternative Parents
Oxanes / Secondary alcohols / Hemiacetals / Polyols / Oxacyclic compounds / Primary alcohols / Hydrocarbon derivatives
Substituents
Alcohol / Aliphatic heteromonocyclic compound / Hemiacetal / Hexose monosaccharide / Hydrocarbon derivative / Organoheterocyclic compound / Oxacycle / Oxane / Polyol / Primary alcohol
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
D-glucopyranose (CHEBI:15903)

Chemical Identifiers

UNII
J4R00M814D
CAS number
492-61-5
InChI Key
WQZGKKKJIJFFOK-VFUOTHLCSA-N
InChI
InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
IUPAC Name
(2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
SMILES
OC[[email protected]]1O[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)[[email protected]@H]1O

References

Synthesis Reference

Chen Gong, "Method for preparation of 2'-deoxy-2', 2'-difluoro-beta-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-beta-D-glucose as raw material." U.S. Patent US20060003963, issued January 05, 2006.

US20060003963
General References
Not Available
Human Metabolome Database
HMDB0000516
KEGG Drug
D00009
KEGG Compound
C00221
PubChem Compound
64689
PubChem Substance
46505414
ChemSpider
58238
BindingDB
50240803
RxNav
1442190
ChEBI
15903
ChEMBL
CHEMBL1614854
ZINC
ZINC000003833800
PDBe Ligand
BGC
PDB Entries
1aa5 / 1abr / 1ac0 / 1au1 / 1ax1 / 1b1y / 1b2y / 1bag / 1bg3 / 1bg9 …
show 1158 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Undifferentiated Leukemia (AUL) / Childhood T Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative1
3Active Not RecruitingTreatmentAcute Myeloid Leukemia (AML) / Granulocytic Sarcoma / Leukaemia cutis / Myeloid Neoplasm1
3Active Not RecruitingTreatmentAdult T Acute Lymphoblastic Leukemia / Ann Arbor Stage II Adult Lymphoblastic Lymphoma / Ann Arbor Stage II Childhood Lymphoblastic Lymphoma / Ann Arbor Stage III Adult Lymphoblastic Lymphoma / Ann Arbor Stage III Childhood Lymphoblastic Lymphoma / Ann Arbor Stage IV Adult Lymphoblastic Lymphoma / Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma / Childhood T Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentAnaplastic Ependymoma / Brain Ependymoma / Cellular Ependymoma / Clear Cell Ependymoma / Ependymomas / Papillary Ependymoma1
3Active Not RecruitingTreatmentAnn Arbor Stage IIB Hodgkin Lymphoma / Ann Arbor Stage IIIB Hodgkin Lymphoma / Ann Arbor Stage IV Hodgkin Lymphoma / Ann Arbor Stage IVA Hodgkin Lymphoma / Ann Arbor Stage IVB Hodgkin Lymphoma / Childhood Hodgkin Lymphoma / Classic Hodgkin Lymphoma1
3Active Not RecruitingTreatmentB Acute Lymphoblastic Leukemia / Central Nervous System Leukemia / Ph-Like Acute Lymphoblastic Leukemia / Testicular Leukemia1
3Active Not RecruitingTreatmentChildhood Atypical Teratoid/Rhabdoid Tumor1
3Active Not RecruitingTreatmentExtraocular Retinoblastoma1
3Active Not RecruitingTreatmentLocalized Resectable Neuroblastoma / Localized Unresectable Neuroblastoma / Recurrent Neuroblastoma / Regional Neuroblastoma / Stage 4 Neuroblastoma / Stage 4S Neuroblastoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)83 °CPhysProp
water solubility1.2E+006 mg/L (at 30 °C)MULLIN,JW (1972)
logP-3.24SANGSTER (1994)
logS0.74ADME Research, USCD
pKa12.9 (at 0 °C)KORTUM,G ET AL (1961)
Predicted Properties
PropertyValueSource
Water Solubility782.0 mg/mLALOGPS
logP-2.6ALOGPS
logP-2.9ChemAxon
logS0.64ALOGPS
pKa (Strongest Acidic)11.3ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area110.38 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity35.92 m3·mol-1ChemAxon
Polarizability16.43 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-9721000000-6ca4df9ac892160d11c5
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-9621000000-fff85ff382393ec04a54
Mass Spectrum (Electron Ionization)MSsplash10-03kc-9000000000-a60df7b043f8947d6909
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-01q9-0900000000-ecd0aedc67c9a2eec60f
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-03ea-2900000000-e4daf22c7320ccc41812
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0005-9200000000-91fc3940732f782a88bb
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-1900000000-e9f3e728d1b340759a09
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-01t9-5900000000-c0a478f2b9c5bbc6c4ba
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9100000000-06852e2088bf1c6b38c4

Targets

Details1. Glycogen phosphorylase, muscle form
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Pyridoxal phosphate binding
Specific Function
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known ...
Gene Name
PYGM
Uniprot ID
P11217
Uniprot Name
Glycogen phosphorylase, muscle form
Molecular Weight
97091.265 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details2. Xylose isomerase
Kind
Protein
Organism
Streptomyces olivochromogenes
Pharmacological action
Unknown
General Function
Xylose isomerase activity
Specific Function
Involved in D-xylose catabolism.
Gene Name
xylA
Uniprot ID
P15587
Uniprot Name
Xylose isomerase
Molecular Weight
42922.7 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details3. Glucokinase
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Glucose binding
Specific Function
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when gluco...
Gene Name
GCK
Uniprot ID
P35557
Uniprot Name
Glucokinase
Molecular Weight
52191.07 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details4. Ferrichrome-iron receptor
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Virion binding
Specific Function
This receptor binds the ferrichrome-iron ligand. It interacts with the TonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor f...
Gene Name
fhuA
Uniprot ID
P06971
Uniprot Name
Ferrichrome-iron receptor
Molecular Weight
82181.75 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details5. Aldose 1-epimerase
Kind
Protein
Organism
Lactococcus lactis
Pharmacological action
Unknown
General Function
Carbohydrate binding
Specific Function
Converts alpha-aldose to the beta-anomer.
Gene Name
galM
Uniprot ID
Q9ZB17
Uniprot Name
Aldose 1-epimerase
Molecular Weight
37610.85 Da
Details6. Possible cellulase CelA1 (Endoglucanase) (Endo-1,4-beta-glucanase) (FI-cmcase) (Carboxymethyl cellulase)
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
Unknown
General Function
Cellulase activity
Specific Function
Not Available
Gene Name
celA1
Uniprot ID
Q79G13
Uniprot Name
Possible cellulase CelA1 (Endoglucanase) (Endo-1,4-beta-glucanase) (FI-cmcase) (Carboxymethyl cellulase)
Molecular Weight
39973.515 Da
Details7. Glucokinase
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Glucokinase activity
Specific Function
Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate.
Gene Name
glk
Uniprot ID
P0A6V8
Uniprot Name
Glucokinase
Molecular Weight
34722.76 Da
Details8. Amylase
Kind
Protein
Organism
Bacillus sp.
Pharmacological action
Unknown
General Function
Hydrolase activity, hydrolyzing o-glycosyl compounds
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
O82839
Uniprot Name
Amylase
Molecular Weight
58841.335 Da
Details9. Fucose-binding lectin PA-IIL
Kind
Protein
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
lecB
Uniprot ID
Q9HYN5
Uniprot Name
Fucose-binding lectin PA-IIL
Molecular Weight
11862.99 Da
Details10. BH0236 protein
Kind
Protein
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Pharmacological action
Unknown
General Function
Glucan endo-1,4-beta-glucanase activity, c-3 substituted reducing group
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q9KG76
Uniprot Name
BH0236 protein
Molecular Weight
114875.925 Da
Details11. Laminarinase
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q9WXN1
Uniprot Name
Laminarinase
Molecular Weight
72539.765 Da
Details12. Endo-1,4-beta-xylanase A
Kind
Protein
Organism
Clostridium stercorarium
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Endoxylanase that degrades arabinoxylan and glucuronoxylan to xylobiose and xylotriose (in vitro).
Gene Name
xynA
Uniprot ID
Q8GJ44
Uniprot Name
Endo-1,4-beta-xylanase A
Molecular Weight
70150.25 Da
Details13. Cellulase B
Kind
Protein
Organism
Cellvibrio mixtus
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
celB
Uniprot ID
O07653
Uniprot Name
Cellulase B
Molecular Weight
65888.415 Da
Details14. Endoglucanase C
Kind
Protein
Organism
Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547)
Pharmacological action
Unknown
General Function
Cellulase activity
Specific Function
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases th...
Gene Name
cenC
Uniprot ID
P14090
Uniprot Name
Endoglucanase C
Molecular Weight
115215.07 Da
Details15. Cellulose 1,4-beta-cellobiosidase (reducing end) CelS
Kind
Protein
Organism
Clostridium thermocellum
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
This enzyme catalyzes the exohydrolysis of 1,4-beta-glucosidic linkages in cellulose with a preference for amorphous or crystalline cellulose over carboxymethyl cellulose.
Gene Name
celS
Uniprot ID
P0C2S5
Uniprot Name
Cellulose 1,4-beta-cellobiosidase (reducing end) CelS
Molecular Weight
83557.84 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details16. D-galactose-binding periplasmic protein
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor.
Gene Name
mglB
Uniprot ID
P0AEE5
Uniprot Name
D-galactose-binding periplasmic protein
Molecular Weight
35712.285 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details17. Glycosyltransferase 6 domain-containing protein 1
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Transferase activity, transferring hexosyl groups
Specific Function
Not Available
Gene Name
GLT6D1
Uniprot ID
Q7Z4J2
Uniprot Name
Glycosyltransferase 6 domain-containing protein 1
Molecular Weight
36273.575 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details18. Glucosamine-6-phosphate isomerase 1
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Hydrolase activity
Specific Function
Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
Gene Name
GNPDA1
Uniprot ID
P46926
Uniprot Name
Glucosamine-6-phosphate isomerase 1
Molecular Weight
32668.29 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details19. Beta-amylase
Kind
Protein
Organism
Bacillus cereus
Pharmacological action
Unknown
General Function
Starch binding
Specific Function
Not Available
Gene Name
spoII
Uniprot ID
P36924
Uniprot Name
Beta-amylase
Molecular Weight
61628.585 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details20. ADP-ribose pyrophosphatase, mitochondrial
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Adp-sugar diphosphatase activity
Specific Function
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Gene Name
NUDT9
Uniprot ID
Q9BW91
Uniprot Name
ADP-ribose pyrophosphatase, mitochondrial
Molecular Weight
39124.685 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details21. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Helicase activity
Specific Function
Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact h...
Gene Name
SMARCA5
Uniprot ID
O60264
Uniprot Name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
Molecular Weight
121904.335 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details22. Cyclomaltodextrin glucanotransferase
Kind
Protein
Organism
Thermoanaerobacter thermosulfurogenes
Pharmacological action
Unknown
General Function
Starch binding
Specific Function
Degrades starch to alpha-, beta-, and gamma-cyclodextrins, as well as linear sugars.
Gene Name
amyA
Uniprot ID
P26827
Uniprot Name
Cyclomaltodextrin glucanotransferase
Molecular Weight
78416.955 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details23. Enterotoxin type B
Kind
Protein
Organism
Staphylococcus aureus
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
Gene Name
entB
Uniprot ID
P01552
Uniprot Name
Enterotoxin type B
Molecular Weight
31435.675 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details24. Alpha-amylase 1
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
AMY1A
Uniprot ID
P04745
Uniprot Name
Alpha-amylase 1
Molecular Weight
57767.49 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details25. Maltodextrin phosphorylase
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Pyridoxal phosphate binding
Specific Function
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known ...
Gene Name
malP
Uniprot ID
P00490
Uniprot Name
Maltodextrin phosphorylase
Molecular Weight
90521.74 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details26. Shiga-like toxin 1 subunit B
Kind
Protein
Organism
Bacteriophage H30
Pharmacological action
Unknown
General Function
Not Available
Specific Function
The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
Gene Name
stxB
Uniprot ID
P69178
Uniprot Name
Shiga-like toxin 1 subunit B
Molecular Weight
9743.07 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details27. Neurocan core protein
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Hyaluronic acid binding
Specific Function
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Gene Name
NCAN
Uniprot ID
O14594
Uniprot Name
Neurocan core protein
Molecular Weight
143092.14 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details28. Beta-glucanase
Kind
Protein
Organism
Paenibacillus macerans
Pharmacological action
Unknown
General Function
Licheninase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
P23904
Uniprot Name
Beta-glucanase
Molecular Weight
26588.59 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details29. Quinoprotein glucose dehydrogenase B
Kind
Protein
Organism
Acinetobacter calcoaceticus
Pharmacological action
Unknown
General Function
Quinoprotein glucose dehydrogenase activity
Specific Function
Oxidizes glucose to gluconolactone.
Gene Name
gdhB
Uniprot ID
P13650
Uniprot Name
Quinoprotein glucose dehydrogenase B
Molecular Weight
52772.255 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details30. Alpha-amylase
Kind
Protein
Organism
Bacillus amyloliquefaciens
Pharmacological action
Unknown
General Function
Calcium ion binding
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
P00692
Uniprot Name
Alpha-amylase
Molecular Weight
58402.605 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details31. DNA
Kind
Nucleotide
Organism
Humans
Pharmacological action
Unknown
DNA is the molecule of heredity, as it is responsible for the genetic propagation of most inherited traits. It is a polynucleic acid that carries genetic information on cell growth, division, and function. DNA consists of two long strands of nucleotides twisted into a double helix and held together by hydrogen bonds. The sequence of nucleotides determines hereditary characteristics. Each strand serves as the template for subsequent DNA replication and as a template for mRNA production, leading to protein synthesis via ribosomes.
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details32. Alpha-amylase
Kind
Protein
Organism
Pseudoalteromonas haloplanktis
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
amy
Uniprot ID
P29957
Uniprot Name
Alpha-amylase
Molecular Weight
73267.4 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details33. Cellulase B
Kind
Protein
Organism
Streptomyces lividans
Pharmacological action
Unknown
General Function
Polysaccharide binding
Specific Function
Not Available
Gene Name
celB
Uniprot ID
Q54331
Uniprot Name
Cellulase B
Molecular Weight
39239.03 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details34. Chondroitinase-B
Kind
Protein
Organism
Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)
Pharmacological action
Unknown
General Function
Chondroitin b lyase activity
Specific Function
Cleaves the glycosaminoglycan, dermatan sulfate.
Gene Name
cslB
Uniprot ID
Q46079
Uniprot Name
Chondroitinase-B
Molecular Weight
56336.075 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details35. Aspartate ammonia-lyase
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Aspartate ammonia-lyase activity
Specific Function
Not Available
Gene Name
aspA
Uniprot ID
P0AC38
Uniprot Name
Aspartate ammonia-lyase
Molecular Weight
52355.755 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details36. Endoglucanase 5A
Kind
Protein
Organism
Bacillus agaradhaerens
Pharmacological action
Unknown
General Function
Cellulase activity
Specific Function
Not Available
Gene Name
cel5A
Uniprot ID
O85465
Uniprot Name
Endoglucanase 5A
Molecular Weight
44701.845 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details37. Lactase-like protein
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Hydrolase activity, hydrolyzing o-glycosyl compounds
Specific Function
Not Available
Gene Name
LCTL
Uniprot ID
Q6UWM7
Uniprot Name
Lactase-like protein
Molecular Weight
65087.84 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details38. Amylosucrase
Kind
Protein
Organism
Neisseria polysaccharea
Pharmacological action
Unknown
General Function
Cation binding
Specific Function
Catalyzes the synthesis of alpha-glucan from sucrose. Catalyzes, in addition, sucrose hydrolysis, maltose and maltotriose synthesis by successive transfers of the glucosyl moiety of sucrose onto th...
Gene Name
ams
Uniprot ID
Q9ZEU2
Uniprot Name
Amylosucrase
Molecular Weight
72343.005 Da
Details39. Pancreatic alpha-amylase
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Chloride ion binding
Specific Function
Not Available
Gene Name
AMY2A
Uniprot ID
P04746
Uniprot Name
Pancreatic alpha-amylase
Molecular Weight
57706.51 Da
Details40. Putative monooxygenase MoxC
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Specific Function
May play a role in methionine degradation. May play a role in a sulfur salvage pathway.
Gene Name
moxC
Uniprot ID
O34974
Uniprot Name
Putative monooxygenase MoxC
Molecular Weight
49410.955 Da
Details41. Endoglucanase E1
Kind
Protein
Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Pharmacological action
Unknown
General Function
Polysaccharide binding
Specific Function
Has a very high specific activity on carboxymethylcellulose.
Gene Name
Not Available
Uniprot ID
P54583
Uniprot Name
Endoglucanase E1
Molecular Weight
60747.355 Da
Details42. D-galactose-binding periplasmic protein
Kind
Protein
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor.
Gene Name
mglB
Uniprot ID
P23905
Uniprot Name
D-galactose-binding periplasmic protein
Molecular Weight
35813.375 Da
Details43. Ecotin
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Serine-type endopeptidase inhibitor activity
Specific Function
General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear...
Gene Name
eco
Uniprot ID
P23827
Uniprot Name
Ecotin
Molecular Weight
18191.925 Da
Details44. A/G-specific adenine glycosylase
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dG...
Gene Name
mutY
Uniprot ID
P17802
Uniprot Name
Adenine DNA glycosylase
Molecular Weight
39148.835 Da
Details45. Keratin-associated protein 5-2
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Not Available
Specific Function
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a...
Gene Name
KRTAP5-2
Uniprot ID
Q701N4
Uniprot Name
Keratin-associated protein 5-2
Molecular Weight
16270.68 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details46. Sialoadhesin
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Carbohydrate binding
Specific Function
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, m...
Gene Name
SIGLEC1
Uniprot ID
Q9BZZ2
Uniprot Name
Sialoadhesin
Molecular Weight
182622.32 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details47. Neopullulanase
Kind
Protein
Organism
Geobacillus stearothermophilus
Pharmacological action
Unknown
General Function
Neopullulanase activity
Specific Function
Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form m...
Gene Name
nplT
Uniprot ID
P38940
Uniprot Name
Neopullulanase
Molecular Weight
69144.625 Da
Details48. Endo-1,4-beta-xylanase A
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Endo-1,4-beta-xylanase activity
Specific Function
Not Available
Gene Name
xynA
Uniprot ID
Q60037
Uniprot Name
Endo-1,4-beta-xylanase A
Molecular Weight
119642.43 Da
Details49. Maltoporin
Kind
Protein
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Pharmacological action
Unknown
General Function
Maltose transporting porin activity
Specific Function
Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages.
Gene Name
lamB
Uniprot ID
P26466
Uniprot Name
Maltoporin
Molecular Weight
50548.715 Da
Details50. Hexokinase
Kind
Protein
Organism
Blood fluke
Pharmacological action
Unknown
General Function
Hexokinase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q26609
Uniprot Name
Hexokinase
Molecular Weight
50445.62 Da
Details51. Neopullulanase 1
Kind
Protein
Organism
Thermoactinomyces vulgaris
Pharmacological action
Unknown
General Function
Neopullulanase activity
Specific Function
Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Also hydrolyzes cyclodextrins.
Gene Name
tvaI
Uniprot ID
Q60053
Uniprot Name
Neopullulanase 1
Molecular Weight
74295.435 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details52. Endo-1,4-beta-xylanase
Kind
Protein
Organism
Geobacillus stearothermophilus
Pharmacological action
Unknown
General Function
Endo-1,4-beta-xylanase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
P40943
Uniprot Name
Endo-1,4-beta-xylanase
Molecular Weight
46763.15 Da
Details53. Cyclomaltodextrin glucanotransferase
Kind
Protein
Organism
Bacillus circulans
Pharmacological action
Unknown
General Function
Starch binding
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
P30920
Uniprot Name
Cyclomaltodextrin glucanotransferase
Molecular Weight
78046.265 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details54. Maltoporin
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Virus receptor activity
Specific Function
Involved in the transport of maltose and maltodextrins, indispensable for translocation of dextrins containing more than three glucosyl moieties. A hydrophobic path ("greasy slide") of aromatic res...
Gene Name
lamB
Uniprot ID
P02943
Uniprot Name
Maltoporin
Molecular Weight
49912.005 Da
Details55. Myoglobin
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Oxygen transporter activity
Specific Function
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
Gene Name
MB
Uniprot ID
P02144
Uniprot Name
Myoglobin
Molecular Weight
17183.725 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details56. Galectin-2
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Galactoside binding
Specific Function
This protein binds beta-galactoside. Its physiological function is not yet known.
Gene Name
LGALS2
Uniprot ID
P05162
Uniprot Name
Galectin-2
Molecular Weight
14644.375 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details57. Prostaglandin G/H synthase 1
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gas...
Gene Name
PTGS1
Uniprot ID
P23219
Uniprot Name
Prostaglandin G/H synthase 1
Molecular Weight
68685.82 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details58. Hexokinase-1
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Mannokinase activity
Specific Function
Not Available
Gene Name
HK1
Uniprot ID
P19367
Uniprot Name
Hexokinase-1
Molecular Weight
102485.1 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details59. Malto-oligosyltrehalose trehalohydrolase
Kind
Protein
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Pharmacological action
Unknown
General Function
Cation binding
Specific Function
Not Available
Gene Name
treZ
Uniprot ID
Q9RX51
Uniprot Name
Malto-oligosyltrehalose trehalohydrolase
Molecular Weight
66909.235 Da
Details60. Alpha-amylase
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
amyE
Uniprot ID
P00691
Uniprot Name
Alpha-amylase
Molecular Weight
72377.4 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details61. Inorganic polyphosphate/ATP-glucomannokinase
Kind
Protein
Organism
Arthrobacter sp. (strain KM)
Pharmacological action
Unknown
General Function
Kinase activity
Specific Function
Not Available
Gene Name
ppgmk
Uniprot ID
Q7WT42
Uniprot Name
Inorganic polyphosphate/ATP-glucomannokinase
Molecular Weight
27995.82 Da
Details62. Exoglucanase/xylanase
Kind
Protein
Organism
Cellulomonas fimi
Pharmacological action
Unknown
General Function
Polysaccharide binding
Specific Function
Hydrolyzes both cellulose and xylan. Has also weak endoglucanase activity.The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases ...
Gene Name
cex
Uniprot ID
P07986
Uniprot Name
Exoglucanase/xylanase
Molecular Weight
51290.845 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details63. Diacetyl reductase [(S)-acetoin forming]
Kind
Protein
Organism
Klebsiella pneumoniae
Pharmacological action
Unknown
General Function
Diacetyl reductase ((s)-acetoin forming) activity
Specific Function
Catalyzes the reversible reduction of (S)-acetoin to 2,3-butanediol in the presence of NADH.
Gene Name
budC
Uniprot ID
Q48436
Uniprot Name
Diacetyl reductase [(S)-acetoin forming]
Molecular Weight
26642.245 Da
Details64. Cyclomaltodextrin glucanotransferase
Kind
Protein
Organism
Bacillus sp. (strain 1011)
Pharmacological action
Unknown
General Function
Starch binding
Specific Function
Not Available
Gene Name
cgt
Uniprot ID
P05618
Uniprot Name
Cyclomaltodextrin glucanotransferase
Molecular Weight
78340.03 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details65. Capsid protein VP1
Kind
Protein
Organism
MPyV
Pharmacological action
Unknown
General Function
Structural molecule activity
Specific Function
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interac...
Gene Name
Not Available
Uniprot ID
P49302
Uniprot Name
Capsid protein VP1
Molecular Weight
42505.275 Da
Details66. Endoglucanase G
Kind
Protein
Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Pharmacological action
Unknown
General Function
Cellulose binding
Specific Function
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases th...
Gene Name
celCCG
Uniprot ID
P37700
Uniprot Name
Endoglucanase G
Molecular Weight
79775.34 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details67. Hydrolase
Kind
Protein
Organism
Streptomyces olivaceoviridis
Pharmacological action
Unknown
General Function
Endo-1,4-beta-xylanase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q7SI98
Uniprot Name
Beta-xylanase
Molecular Weight
46749.175 Da
Details68. Galectin-7
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Carbohydrate binding
Specific Function
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c ...
Gene Name
LGALS7
Uniprot ID
P47929
Uniprot Name
Galectin-7
Molecular Weight
15074.965 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details69. Cholera enterotoxin subunit B
Kind
Protein
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Pharmacological action
Unknown
General Function
Host cell surface binding
Specific Function
The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It...
Gene Name
ctxB
Uniprot ID
P01556
Uniprot Name
Cholera enterotoxin subunit B
Molecular Weight
13957.055 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details70. Keratin-associated protein 5-3
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Not Available
Specific Function
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a...
Gene Name
KRTAP5-3
Uniprot ID
Q6L8H2
Uniprot Name
Keratin-associated protein 5-3
Molecular Weight
22105.295 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details71. Dimethyl sulfoxide/trimethylamine N-oxide reductase
Kind
Protein
Organism
Rhodobacter sphaeroides
Pharmacological action
Unknown
General Function
Trimethylamine-n-oxide reductase (cytochrome c) activity
Specific Function
Catalyzes the reduction of dimethyl sulfoxide (DMSO) and trimethylamine N-oxide (TMAO) to dimethyl sulfide (DMS) and trimethylamine, respectively. The terminal DMSO reductase can also use various s...
Gene Name
dmsA
Uniprot ID
Q57366
Uniprot Name
Dimethyl sulfoxide/trimethylamine N-oxide reductase
Molecular Weight
89206.805 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details72. Endoglucanase C307
Kind
Protein
Organism
Clostridium sp. (strain F1)
Pharmacological action
Unknown
General Function
Cellulase activity
Specific Function
This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Gene Name
celC307
Uniprot ID
P23340
Uniprot Name
Endoglucanase C307
Molecular Weight
40905.03 Da
Details73. Alpha-amylase 2B
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Alpha-amylase activity
Gene Name
AMY2B
Uniprot ID
P19961
Uniprot Name
Alpha-amylase 2B
Molecular Weight
57709.49 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Details74. Endo-1,4-beta glucanase EngF
Kind
Protein
Organism
Clostridium cellulovorans
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
engF
Uniprot ID
P94622
Uniprot Name
Endo-1,4-beta glucanase EngF
Molecular Weight
60130.5 Da
Details75. Neopullulanase 2
Kind
Protein
Organism
Thermoactinomyces vulgaris
Pharmacological action
Unknown
General Function
Neopullulanase activity
Specific Function
Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form m...
Gene Name
tvaII
Uniprot ID
Q08751
Uniprot Name
Neopullulanase 2
Molecular Weight
67466.71 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details76. Endoglucanase E-4
Kind
Protein
Organism
Thermomonospora fusca
Pharmacological action
Unknown
General Function
Cellulose binding
Specific Function
Not Available
Gene Name
celD
Uniprot ID
P26221
Uniprot Name
Endoglucanase E-4
Molecular Weight
95201.875 Da
Details77. Botulinum neurotoxin type B
Kind
Protein
Organism
Clostridium botulinum
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it ca...
Gene Name
botB
Uniprot ID
P10844
Uniprot Name
Botulinum neurotoxin type B
Molecular Weight
150801.16 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details78. Orf protein
Kind
Protein
Organism
Escherichia coli
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
stx2eB
Uniprot ID
Q47644
Uniprot Name
Orf protein
Molecular Weight
9650.1 Da
Details79. Tetanus toxin
Kind
Protein
Organism
Clostridium tetani (strain Massachusetts / E88)
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can ...
Gene Name
tetX
Uniprot ID
P04958
Uniprot Name
Tetanus toxin
Molecular Weight
150680.98 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details80. Xylose isomerase
Kind
Protein
Organism
Streptomyces rubiginosus
Pharmacological action
Unknown
General Function
Xylose isomerase activity
Specific Function
Involved in D-xylose catabolism.
Gene Name
xylA
Uniprot ID
P24300
Uniprot Name
Xylose isomerase
Molecular Weight
43226.915 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details81. Glucan 1,4-alpha-maltohexaosidase
Kind
Protein
Organism
Bacillus sp. (strain 707)
Pharmacological action
Unknown
General Function
Glucan 1,4-alpha-maltohexaosidase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
P19571
Uniprot Name
Glucan 1,4-alpha-maltohexaosidase
Molecular Weight
59008.445 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details82. Glucan 1,4-alpha-maltotetraohydrolase
Kind
Protein
Organism
Pseudomonas stutzeri
Pharmacological action
Unknown
General Function
Starch binding
Specific Function
Not Available
Gene Name
amyP
Uniprot ID
P13507
Uniprot Name
Glucan 1,4-alpha-maltotetraohydrolase
Molecular Weight
59875.725 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details83. Endoglucanase F
Kind
Protein
Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Pharmacological action
Unknown
General Function
Cellulase activity
Specific Function
Probable endoglucanase involved in the degradation of cellulose or related beta-glucans.
Gene Name
celCCF
Uniprot ID
P37698
Uniprot Name
Endoglucanase F
Molecular Weight
80543.885 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details84. Glucose--fructose oxidoreductase
Kind
Protein
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Pharmacological action
Unknown
General Function
Glucose-fructose oxidoreductase activity
Specific Function
Not Available
Gene Name
gfo
Uniprot ID
Q07982
Uniprot Name
Glucose--fructose oxidoreductase
Molecular Weight
47189.15 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details85. Bifunctional tail protein
Kind
Protein
Organism
Enterobacteria phage P22
Pharmacological action
Unknown
General Function
Hydrolase activity, acting on glycosyl bonds
Specific Function
Structural component of the short non-contractile tail. The tail comprises six fibers that mediate primary attachment to the host cell lipopolysaccharides (LPS) and display endorhamnosidase enzymat...
Gene Name
9
Uniprot ID
P12528
Uniprot Name
Tail fiber protein
Molecular Weight
71856.28 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details86. Glycogen phosphorylase, liver form
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Vitamin binding
Specific Function
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known ...
Gene Name
PYGL
Uniprot ID
P06737
Uniprot Name
Glycogen phosphorylase, liver form
Molecular Weight
97147.82 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details87. Pulmonary surfactant-associated protein D
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Carbohydrate binding
Specific Function
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and m...
Gene Name
SFTPD
Uniprot ID
P35247
Uniprot Name
Pulmonary surfactant-associated protein D
Molecular Weight
37728.19 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details88. Interferon beta
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Type i interferon receptor binding
Specific Function
Has antiviral, antibacterial and anticancer activities.
Gene Name
IFNB1
Uniprot ID
P01574
Uniprot Name
Interferon beta
Molecular Weight
22293.68 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details89. Maltose-binding periplasmic protein
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Transporter activity
Specific Function
Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
Gene Name
malE
Uniprot ID
P0AEX9
Uniprot Name
Maltose-binding periplasmic protein
Molecular Weight
43387.235 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details90. Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Identical protein binding
Specific Function
Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used i...
Gene Name
fabI
Uniprot ID
P0AEK4
Uniprot Name
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Molecular Weight
27863.645 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details91. Endoglucanase A
Kind
Protein
Organism
Clostridium thermocellum
Pharmacological action
Unknown
General Function
Cellulase activity
Specific Function
This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Gene Name
celA
Uniprot ID
P0C2S2
Uniprot Name
Endoglucanase A
Molecular Weight
1449.625 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Enzymes

Details1. Pancreatic alpha-amylase
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Chloride ion binding
Specific Function
Not Available
Gene Name
AMY2A
Uniprot ID
P04746
Uniprot Name
Pancreatic alpha-amylase
Molecular Weight
57706.51 Da
References
  1. Zajoncova L, Jilek M, Beranova V, Pec P: A biosensor for the determination of amylase activity. Biosens Bioelectron. 2004 Sep 15;20(2):240-5. doi: 10.1016/j.bios.2004.01.006. [PubMed:15308227]
  2. Pierzynowski SG, Goncharova K, Gregory PC, Westrom B, Podpryatov SE, Podpriatov SS, Wolinski J, Repich H, Wierup N, Lozinska L: Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model. Sci Rep. 2017 Aug 17;7(1):8628. doi: 10.1038/s41598-017-07387-2. [PubMed:28819193]
  3. Date K, Satoh A, Iida K, Ogawa H: Pancreatic alpha-Amylase Controls Glucose Assimilation by Duodenal Retrieval through N-Glycan-specific Binding, Endocytosis, and Degradation. J Biol Chem. 2015 Jul 10;290(28):17439-50. doi: 10.1074/jbc.M114.594937. Epub 2015 May 28. [PubMed:26023238]

Drug created on June 13, 2005 07:24 / Updated on July 02, 2020 07:15

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