Beta-D-Glucose
Identification
- Name
- Beta-D-Glucose
- Accession Number
- DB02379
- Description
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Beta-D-Glucose (DB02379)
- Weight
- Average: 180.1559
Monoisotopic: 180.063388116 - Chemical Formula
- C6H12O6
- Synonyms
- beta-D-glucopyranose
- Beta-D-glucose anhydrous
- Beta-D-glucose, anhydrous
- Glucoside
- β-D-glucose
Pharmacology
Accelerate your drug discovery research with the industry’s only fully connected ADMET dataset, ideal for:Accelerate your drug discovery research with our fully connected ADMET dataset- Indication
- Not Available
- Contraindications & Blackbox Warnings
Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects- Pharmacodynamics
- Not Available
- Mechanism of action
Target Actions Organism UGlycogen phosphorylase, muscle form Not Available Humans UXylose isomerase Not Available Streptomyces olivochromogenes UGlucokinase Not Available Humans UFerrichrome-iron receptor Not Available Escherichia coli (strain K12) UAldose 1-epimerase Not Available Lactococcus lactis UPossible cellulase CelA1 (Endoglucanase) (Endo-1,4-beta-glucanase) (FI-cmcase) (Carboxymethyl cellulase) Not Available Mycobacterium tuberculosis UGlucokinase Not Available Escherichia coli (strain K12) UAmylase Not Available Bacillus sp. UFucose-binding lectin PA-IIL Not Available Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) UBH0236 protein Not Available Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) ULaminarinase Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UEndo-1,4-beta-xylanase A Not Available Clostridium stercorarium UCellulase B Not Available Cellvibrio mixtus UEndoglucanase C Not Available Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547) UCellulose 1,4-beta-cellobiosidase (reducing end) CelS Not Available Clostridium thermocellum UD-galactose-binding periplasmic protein Not Available Escherichia coli (strain K12) UGlycosyltransferase 6 domain-containing protein 1 Not Available Humans UGlucosamine-6-phosphate isomerase 1 Not Available Humans UBeta-amylase Not Available Bacillus cereus UADP-ribose pyrophosphatase, mitochondrial Not Available Humans USWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Not Available Humans UCyclomaltodextrin glucanotransferase Not Available Thermoanaerobacter thermosulfurogenes UEnterotoxin type B Not Available Staphylococcus aureus UAlpha-amylase 1 Not Available Humans UMaltodextrin phosphorylase Not Available Escherichia coli (strain K12) UShiga-like toxin 1 subunit B Not Available Bacteriophage H30 UNeurocan core protein Not Available Humans UBeta-glucanase Not Available Paenibacillus macerans UQuinoprotein glucose dehydrogenase B Not Available Acinetobacter calcoaceticus UAlpha-amylase Not Available Bacillus amyloliquefaciens UDNA Not Available Humans UAlpha-amylase Not Available Pseudoalteromonas haloplanktis UCellulase B Not Available Streptomyces lividans UChondroitinase-B Not Available Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290) UAspartate ammonia-lyase Not Available Escherichia coli (strain K12) UEndoglucanase 5A Not Available Bacillus agaradhaerens ULactase-like protein Not Available Humans UAmylosucrase Not Available Neisseria polysaccharea UPancreatic alpha-amylase Not Available Humans UPutative monooxygenase MoxC Not Available Bacillus subtilis (strain 168) UEndoglucanase E1 Not Available Acidothermus cellulolyticus (strain ATCC 43068 / 11B) UD-galactose-binding periplasmic protein Not Available Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) UEcotin Not Available Escherichia coli (strain K12) UA/G-specific adenine glycosylase Not Available Escherichia coli (strain K12) UKeratin-associated protein 5-2 Not Available Humans USialoadhesin Not Available Humans UNeopullulanase Not Available Geobacillus stearothermophilus UEndo-1,4-beta-xylanase A Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UMaltoporin Not Available Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) UHexokinase Not Available Blood fluke UNeopullulanase 1 Not Available Thermoactinomyces vulgaris UEndo-1,4-beta-xylanase Not Available Geobacillus stearothermophilus UCyclomaltodextrin glucanotransferase Not Available Bacillus circulans UMaltoporin Not Available Escherichia coli (strain K12) UMyoglobin Not Available Humans UGalectin-2 Not Available Humans UProstaglandin G/H synthase 1 Not Available Humans UHexokinase-1 Not Available Humans UMalto-oligosyltrehalose trehalohydrolase Not Available Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) UAlpha-amylase Not Available Bacillus subtilis (strain 168) UInorganic polyphosphate/ATP-glucomannokinase Not Available Arthrobacter sp. (strain KM) UExoglucanase/xylanase Not Available Cellulomonas fimi UDiacetyl reductase [(S)-acetoin forming] Not Available Klebsiella pneumoniae UCyclomaltodextrin glucanotransferase Not Available Bacillus sp. (strain 1011) UCapsid protein VP1 Not Available MPyV UEndoglucanase G Not Available Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) UHydrolase Not Available Streptomyces olivaceoviridis UGalectin-7 Not Available Humans UCholera enterotoxin subunit B Not Available Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) UKeratin-associated protein 5-3 Not Available Humans UDimethyl sulfoxide/trimethylamine N-oxide reductase Not Available Rhodobacter sphaeroides UEndoglucanase C307 Not Available Clostridium sp. (strain F1) UAlpha-amylase 2B Not Available Humans UEndo-1,4-beta glucanase EngF Not Available Clostridium cellulovorans UNeopullulanase 2 Not Available Thermoactinomyces vulgaris UEndoglucanase E-4 Not Available Thermomonospora fusca UBotulinum neurotoxin type B Not Available Clostridium botulinum UOrf protein Not Available Escherichia coli UTetanus toxin Not Available Clostridium tetani (strain Massachusetts / E88) UXylose isomerase Not Available Streptomyces rubiginosus UGlucan 1,4-alpha-maltohexaosidase Not Available Bacillus sp. (strain 707) UGlucan 1,4-alpha-maltotetraohydrolase Not Available Pseudomonas stutzeri UEndoglucanase F Not Available Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) UGlucose--fructose oxidoreductase Not Available Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) UBifunctional tail protein Not Available Enterobacteria phage P22 UGlycogen phosphorylase, liver form Not Available Humans UPulmonary surfactant-associated protein D Not Available Humans UInterferon beta Not Available Humans UMaltose-binding periplasmic protein Not Available Escherichia coli (strain K12) UEnoyl-[acyl-carrier-protein] reductase [NADH] FabI Not Available Escherichia coli (strain K12) UEndoglucanase A Not Available Clostridium thermocellum - Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Reduce medical errorsand improve treatment outcomes with our comprehensive & structured data on drug adverse effects.Reduce medical errors & improve treatment outcomes with our adverse effects data- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Carbohydrates and carbohydrate conjugates
- Direct Parent
- Hexoses
- Alternative Parents
- Oxanes / Secondary alcohols / Hemiacetals / Polyols / Oxacyclic compounds / Primary alcohols / Hydrocarbon derivatives
- Substituents
- Alcohol / Aliphatic heteromonocyclic compound / Hemiacetal / Hexose monosaccharide / Hydrocarbon derivative / Organoheterocyclic compound / Oxacycle / Oxane / Polyol / Primary alcohol
- Molecular Framework
- Aliphatic heteromonocyclic compounds
- External Descriptors
- D-glucopyranose (CHEBI:15903)
Chemical Identifiers
- UNII
- J4R00M814D
- CAS number
- 492-61-5
- InChI Key
- WQZGKKKJIJFFOK-VFUOTHLCSA-N
- InChI
- InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
- IUPAC Name
- (2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
- SMILES
- OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
References
- Synthesis Reference
Chen Gong, "Method for preparation of 2'-deoxy-2', 2'-difluoro-beta-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-beta-D-glucose as raw material." U.S. Patent US20060003963, issued January 05, 2006.
US20060003963- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0000516
- KEGG Drug
- D00009
- KEGG Compound
- C00221
- PubChem Compound
- 64689
- PubChem Substance
- 46505414
- ChemSpider
- 58238
- BindingDB
- 50240803
- 1442190
- ChEBI
- 15903
- ChEMBL
- CHEMBL1614854
- ZINC
- ZINC000003833800
- PDBe Ligand
- BGC
- PDB Entries
- 1aa5 / 1abr / 1ac0 / 1au1 / 1ax1 / 1b1y / 1b2y / 1bag / 1bg3 / 1bg9 … show 1169 more
Clinical Trials
- Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 83 °C PhysProp water solubility 1.2E+006 mg/L (at 30 °C) MULLIN,JW (1972) logP -3.24 SANGSTER (1994) logS 0.74 ADME Research, USCD pKa 12.9 (at 0 °C) KORTUM,G ET AL (1961) - Predicted Properties
Property Value Source Water Solubility 782.0 mg/mL ALOGPS logP -2.6 ALOGPS logP -2.9 ChemAxon logS 0.64 ALOGPS pKa (Strongest Acidic) 11.3 ChemAxon pKa (Strongest Basic) -3 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 6 ChemAxon Hydrogen Donor Count 5 ChemAxon Polar Surface Area 110.38 Å2 ChemAxon Rotatable Bond Count 1 ChemAxon Refractivity 35.92 m3·mol-1 ChemAxon Polarizability 16.43 Å3 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Targets
Accelerate your drug discovery research
with our fully connected ADMET & drug target dataset.
Accelerate your drug discovery research with our ADMET & drug target dataset
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known ...
- Gene Name
- PYGM
- Uniprot ID
- P11217
- Uniprot Name
- Glycogen phosphorylase, muscle form
- Molecular Weight
- 97091.265 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Streptomyces olivochromogenes
- Pharmacological action
- Unknown
- General Function
- Xylose isomerase activity
- Specific Function
- Involved in D-xylose catabolism.
- Gene Name
- xylA
- Uniprot ID
- P15587
- Uniprot Name
- Xylose isomerase
- Molecular Weight
- 42922.7 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Glucose binding
- Specific Function
- Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when gluco...
- Gene Name
- GCK
- Uniprot ID
- P35557
- Uniprot Name
- Glucokinase
- Molecular Weight
- 52191.07 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Virion binding
- Specific Function
- This receptor binds the ferrichrome-iron ligand. It interacts with the TonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor f...
- Gene Name
- fhuA
- Uniprot ID
- P06971
- Uniprot Name
- Ferrichrome-iron receptor
- Molecular Weight
- 82181.75 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Lactococcus lactis
- Pharmacological action
- Unknown
- General Function
- Carbohydrate binding
- Specific Function
- Converts alpha-aldose to the beta-anomer.
- Gene Name
- galM
- Uniprot ID
- Q9ZB17
- Uniprot Name
- Aldose 1-epimerase
- Molecular Weight
- 37610.85 Da
Details6. Possible cellulase CelA1 (Endoglucanase) (Endo-1,4-beta-glucanase) (FI-cmcase) (Carboxymethyl cellulase)
- Kind
- Protein
- Organism
- Mycobacterium tuberculosis
- Pharmacological action
- Unknown
- General Function
- Cellulase activity
- Specific Function
- Not Available
- Gene Name
- celA1
- Uniprot ID
- Q79G13
- Uniprot Name
- Possible cellulase CelA1 (Endoglucanase) (Endo-1,4-beta-glucanase) (FI-cmcase) (Carboxymethyl cellulase)
- Molecular Weight
- 39973.515 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Glucokinase activity
- Specific Function
- Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate.
- Gene Name
- glk
- Uniprot ID
- P0A6V8
- Uniprot Name
- Glucokinase
- Molecular Weight
- 34722.76 Da
- Kind
- Protein
- Organism
- Bacillus sp.
- Pharmacological action
- Unknown
- General Function
- Hydrolase activity, hydrolyzing o-glycosyl compounds
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- O82839
- Uniprot Name
- Amylase
- Molecular Weight
- 58841.335 Da
- Kind
- Protein
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- lecB
- Uniprot ID
- Q9HYN5
- Uniprot Name
- Fucose-binding lectin PA-IIL
- Molecular Weight
- 11862.99 Da
- Kind
- Protein
- Organism
- Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
- Pharmacological action
- Unknown
- General Function
- Glucan endo-1,4-beta-glucanase activity, c-3 substituted reducing group
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9KG76
- Uniprot Name
- BH0236 protein
- Molecular Weight
- 114875.925 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9WXN1
- Uniprot Name
- Laminarinase
- Molecular Weight
- 72539.765 Da
- Kind
- Protein
- Organism
- Clostridium stercorarium
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Endoxylanase that degrades arabinoxylan and glucuronoxylan to xylobiose and xylotriose (in vitro).
- Gene Name
- xynA
- Uniprot ID
- Q8GJ44
- Uniprot Name
- Endo-1,4-beta-xylanase A
- Molecular Weight
- 70150.25 Da
- Kind
- Protein
- Organism
- Cellvibrio mixtus
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- celB
- Uniprot ID
- O07653
- Uniprot Name
- Cellulase B
- Molecular Weight
- 65888.415 Da
- Kind
- Protein
- Organism
- Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547)
- Pharmacological action
- Unknown
- General Function
- Cellulase activity
- Specific Function
- The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases th...
- Gene Name
- cenC
- Uniprot ID
- P14090
- Uniprot Name
- Endoglucanase C
- Molecular Weight
- 115215.07 Da
- Kind
- Protein
- Organism
- Clostridium thermocellum
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- This enzyme catalyzes the exohydrolysis of 1,4-beta-glucosidic linkages in cellulose with a preference for amorphous or crystalline cellulose over carboxymethyl cellulose.
- Gene Name
- celS
- Uniprot ID
- P0C2S5
- Uniprot Name
- Cellulose 1,4-beta-cellobiosidase (reducing end) CelS
- Molecular Weight
- 83557.84 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor.
- Gene Name
- mglB
- Uniprot ID
- P0AEE5
- Uniprot Name
- D-galactose-binding periplasmic protein
- Molecular Weight
- 35712.285 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Transferase activity, transferring hexosyl groups
- Specific Function
- Not Available
- Gene Name
- GLT6D1
- Uniprot ID
- Q7Z4J2
- Uniprot Name
- Glycosyltransferase 6 domain-containing protein 1
- Molecular Weight
- 36273.575 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Hydrolase activity
- Specific Function
- Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
- Gene Name
- GNPDA1
- Uniprot ID
- P46926
- Uniprot Name
- Glucosamine-6-phosphate isomerase 1
- Molecular Weight
- 32668.29 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Bacillus cereus
- Pharmacological action
- Unknown
- General Function
- Starch binding
- Specific Function
- Not Available
- Gene Name
- spoII
- Uniprot ID
- P36924
- Uniprot Name
- Beta-amylase
- Molecular Weight
- 61628.585 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Adp-sugar diphosphatase activity
- Specific Function
- Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
- Gene Name
- NUDT9
- Uniprot ID
- Q9BW91
- Uniprot Name
- ADP-ribose pyrophosphatase, mitochondrial
- Molecular Weight
- 39124.685 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Details21. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Helicase activity
- Specific Function
- Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact h...
- Gene Name
- SMARCA5
- Uniprot ID
- O60264
- Uniprot Name
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- Molecular Weight
- 121904.335 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Thermoanaerobacter thermosulfurogenes
- Pharmacological action
- Unknown
- General Function
- Starch binding
- Specific Function
- Degrades starch to alpha-, beta-, and gamma-cyclodextrins, as well as linear sugars.
- Gene Name
- amyA
- Uniprot ID
- P26827
- Uniprot Name
- Cyclomaltodextrin glucanotransferase
- Molecular Weight
- 78416.955 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Staphylococcus aureus
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
- Gene Name
- entB
- Uniprot ID
- P01552
- Uniprot Name
- Enterotoxin type B
- Molecular Weight
- 31435.675 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- AMY1A
- Uniprot ID
- P04745
- Uniprot Name
- Alpha-amylase 1
- Molecular Weight
- 57767.49 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known ...
- Gene Name
- malP
- Uniprot ID
- P00490
- Uniprot Name
- Maltodextrin phosphorylase
- Molecular Weight
- 90521.74 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Bacteriophage H30
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
- Gene Name
- stxB
- Uniprot ID
- P69178
- Uniprot Name
- Shiga-like toxin 1 subunit B
- Molecular Weight
- 9743.07 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Hyaluronic acid binding
- Specific Function
- May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
- Gene Name
- NCAN
- Uniprot ID
- O14594
- Uniprot Name
- Neurocan core protein
- Molecular Weight
- 143092.14 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Paenibacillus macerans
- Pharmacological action
- Unknown
- General Function
- Licheninase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- P23904
- Uniprot Name
- Beta-glucanase
- Molecular Weight
- 26588.59 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Acinetobacter calcoaceticus
- Pharmacological action
- Unknown
- General Function
- Quinoprotein glucose dehydrogenase activity
- Specific Function
- Oxidizes glucose to gluconolactone.
- Gene Name
- gdhB
- Uniprot ID
- P13650
- Uniprot Name
- Quinoprotein glucose dehydrogenase B
- Molecular Weight
- 52772.255 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Bacillus amyloliquefaciens
- Pharmacological action
- Unknown
- General Function
- Calcium ion binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- P00692
- Uniprot Name
- Alpha-amylase
- Molecular Weight
- 58402.605 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Unknown
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Pseudoalteromonas haloplanktis
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- amy
- Uniprot ID
- P29957
- Uniprot Name
- Alpha-amylase
- Molecular Weight
- 73267.4 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Streptomyces lividans
- Pharmacological action
- Unknown
- General Function
- Polysaccharide binding
- Specific Function
- Not Available
- Gene Name
- celB
- Uniprot ID
- Q54331
- Uniprot Name
- Cellulase B
- Molecular Weight
- 39239.03 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / NCIB 9290)
- Pharmacological action
- Unknown
- General Function
- Chondroitin b lyase activity
- Specific Function
- Cleaves the glycosaminoglycan, dermatan sulfate.
- Gene Name
- cslB
- Uniprot ID
- Q46079
- Uniprot Name
- Chondroitinase-B
- Molecular Weight
- 56336.075 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Aspartate ammonia-lyase activity
- Specific Function
- Not Available
- Gene Name
- aspA
- Uniprot ID
- P0AC38
- Uniprot Name
- Aspartate ammonia-lyase
- Molecular Weight
- 52355.755 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Bacillus agaradhaerens
- Pharmacological action
- Unknown
- General Function
- Cellulase activity
- Specific Function
- Not Available
- Gene Name
- cel5A
- Uniprot ID
- O85465
- Uniprot Name
- Endoglucanase 5A
- Molecular Weight
- 44701.845 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Hydrolase activity, hydrolyzing o-glycosyl compounds
- Specific Function
- Not Available
- Gene Name
- LCTL
- Uniprot ID
- Q6UWM7
- Uniprot Name
- Lactase-like protein
- Molecular Weight
- 65087.84 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Neisseria polysaccharea
- Pharmacological action
- Unknown
- General Function
- Cation binding
- Specific Function
- Catalyzes the synthesis of alpha-glucan from sucrose. Catalyzes, in addition, sucrose hydrolysis, maltose and maltotriose synthesis by successive transfers of the glucosyl moiety of sucrose onto th...
- Gene Name
- ams
- Uniprot ID
- Q9ZEU2
- Uniprot Name
- Amylosucrase
- Molecular Weight
- 72343.005 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Chloride ion binding
- Specific Function
- Not Available
- Gene Name
- AMY2A
- Uniprot ID
- P04746
- Uniprot Name
- Pancreatic alpha-amylase
- Molecular Weight
- 57706.51 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- Specific Function
- May play a role in methionine degradation. May play a role in a sulfur salvage pathway.
- Gene Name
- moxC
- Uniprot ID
- O34974
- Uniprot Name
- Putative monooxygenase MoxC
- Molecular Weight
- 49410.955 Da
- Kind
- Protein
- Organism
- Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
- Pharmacological action
- Unknown
- General Function
- Polysaccharide binding
- Specific Function
- Has a very high specific activity on carboxymethylcellulose.
- Gene Name
- Not Available
- Uniprot ID
- P54583
- Uniprot Name
- Endoglucanase E1
- Molecular Weight
- 60747.355 Da
- Kind
- Protein
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor.
- Gene Name
- mglB
- Uniprot ID
- P23905
- Uniprot Name
- D-galactose-binding periplasmic protein
- Molecular Weight
- 35813.375 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Serine-type endopeptidase inhibitor activity
- Specific Function
- General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear...
- Gene Name
- eco
- Uniprot ID
- P23827
- Uniprot Name
- Ecotin
- Molecular Weight
- 18191.925 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dG...
- Gene Name
- mutY
- Uniprot ID
- P17802
- Uniprot Name
- Adenine DNA glycosylase
- Molecular Weight
- 39148.835 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a...
- Gene Name
- KRTAP5-2
- Uniprot ID
- Q701N4
- Uniprot Name
- Keratin-associated protein 5-2
- Molecular Weight
- 16270.68 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Carbohydrate binding
- Specific Function
- Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, m...
- Gene Name
- SIGLEC1
- Uniprot ID
- Q9BZZ2
- Uniprot Name
- Sialoadhesin
- Molecular Weight
- 182622.32 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Geobacillus stearothermophilus
- Pharmacological action
- Unknown
- General Function
- Neopullulanase activity
- Specific Function
- Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form m...
- Gene Name
- nplT
- Uniprot ID
- P38940
- Uniprot Name
- Neopullulanase
- Molecular Weight
- 69144.625 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Endo-1,4-beta-xylanase activity
- Specific Function
- Not Available
- Gene Name
- xynA
- Uniprot ID
- Q60037
- Uniprot Name
- Endo-1,4-beta-xylanase A
- Molecular Weight
- 119642.43 Da
- Kind
- Protein
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Pharmacological action
- Unknown
- General Function
- Maltose transporting porin activity
- Specific Function
- Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages.
- Gene Name
- lamB
- Uniprot ID
- P26466
- Uniprot Name
- Maltoporin
- Molecular Weight
- 50548.715 Da
- Kind
- Protein
- Organism
- Blood fluke
- Pharmacological action
- Unknown
- General Function
- Hexokinase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q26609
- Uniprot Name
- Hexokinase
- Molecular Weight
- 50445.62 Da
- Kind
- Protein
- Organism
- Thermoactinomyces vulgaris
- Pharmacological action
- Unknown
- General Function
- Neopullulanase activity
- Specific Function
- Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Also hydrolyzes cyclodextrins.
- Gene Name
- tvaI
- Uniprot ID
- Q60053
- Uniprot Name
- Neopullulanase 1
- Molecular Weight
- 74295.435 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Geobacillus stearothermophilus
- Pharmacological action
- Unknown
- General Function
- Endo-1,4-beta-xylanase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- P40943
- Uniprot Name
- Endo-1,4-beta-xylanase
- Molecular Weight
- 46763.15 Da
- Kind
- Protein
- Organism
- Bacillus circulans
- Pharmacological action
- Unknown
- General Function
- Starch binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- P30920
- Uniprot Name
- Cyclomaltodextrin glucanotransferase
- Molecular Weight
- 78046.265 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Virus receptor activity
- Specific Function
- Involved in the transport of maltose and maltodextrins, indispensable for translocation of dextrins containing more than three glucosyl moieties. A hydrophobic path ("greasy slide") of aromatic res...
- Gene Name
- lamB
- Uniprot ID
- P02943
- Uniprot Name
- Maltoporin
- Molecular Weight
- 49912.005 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Oxygen transporter activity
- Specific Function
- Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
- Gene Name
- MB
- Uniprot ID
- P02144
- Uniprot Name
- Myoglobin
- Molecular Weight
- 17183.725 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Galactoside binding
- Specific Function
- This protein binds beta-galactoside. Its physiological function is not yet known.
- Gene Name
- LGALS2
- Uniprot ID
- P05162
- Uniprot Name
- Galectin-2
- Molecular Weight
- 14644.375 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Prostaglandin-endoperoxide synthase activity
- Specific Function
- Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gas...
- Gene Name
- PTGS1
- Uniprot ID
- P23219
- Uniprot Name
- Prostaglandin G/H synthase 1
- Molecular Weight
- 68685.82 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Mannokinase activity
- Specific Function
- Not Available
- Gene Name
- HK1
- Uniprot ID
- P19367
- Uniprot Name
- Hexokinase-1
- Molecular Weight
- 102485.1 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
- Pharmacological action
- Unknown
- General Function
- Cation binding
- Specific Function
- Not Available
- Gene Name
- treZ
- Uniprot ID
- Q9RX51
- Uniprot Name
- Malto-oligosyltrehalose trehalohydrolase
- Molecular Weight
- 66909.235 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- amyE
- Uniprot ID
- P00691
- Uniprot Name
- Alpha-amylase
- Molecular Weight
- 72377.4 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Arthrobacter sp. (strain KM)
- Pharmacological action
- Unknown
- General Function
- Kinase activity
- Specific Function
- Not Available
- Gene Name
- ppgmk
- Uniprot ID
- Q7WT42
- Uniprot Name
- Inorganic polyphosphate/ATP-glucomannokinase
- Molecular Weight
- 27995.82 Da
- Kind
- Protein
- Organism
- Cellulomonas fimi
- Pharmacological action
- Unknown
- General Function
- Polysaccharide binding
- Specific Function
- Hydrolyzes both cellulose and xylan. Has also weak endoglucanase activity.The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases ...
- Gene Name
- cex
- Uniprot ID
- P07986
- Uniprot Name
- Exoglucanase/xylanase
- Molecular Weight
- 51290.845 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Klebsiella pneumoniae
- Pharmacological action
- Unknown
- General Function
- Diacetyl reductase ((s)-acetoin forming) activity
- Specific Function
- Catalyzes the reversible reduction of (S)-acetoin to 2,3-butanediol in the presence of NADH.
- Gene Name
- budC
- Uniprot ID
- Q48436
- Uniprot Name
- Diacetyl reductase [(S)-acetoin forming]
- Molecular Weight
- 26642.245 Da
- Kind
- Protein
- Organism
- Bacillus sp. (strain 1011)
- Pharmacological action
- Unknown
- General Function
- Starch binding
- Specific Function
- Not Available
- Gene Name
- cgt
- Uniprot ID
- P05618
- Uniprot Name
- Cyclomaltodextrin glucanotransferase
- Molecular Weight
- 78340.03 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- MPyV
- Pharmacological action
- Unknown
- General Function
- Structural molecule activity
- Specific Function
- Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interac...
- Gene Name
- Not Available
- Uniprot ID
- P49302
- Uniprot Name
- Capsid protein VP1
- Molecular Weight
- 42505.275 Da
- Kind
- Protein
- Organism
- Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
- Pharmacological action
- Unknown
- General Function
- Cellulose binding
- Specific Function
- The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases th...
- Gene Name
- celCCG
- Uniprot ID
- P37700
- Uniprot Name
- Endoglucanase G
- Molecular Weight
- 79775.34 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Streptomyces olivaceoviridis
- Pharmacological action
- Unknown
- General Function
- Endo-1,4-beta-xylanase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q7SI98
- Uniprot Name
- Beta-xylanase
- Molecular Weight
- 46749.175 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Carbohydrate binding
- Specific Function
- Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c ...
- Gene Name
- LGALS7
- Uniprot ID
- P47929
- Uniprot Name
- Galectin-7
- Molecular Weight
- 15074.965 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
- Pharmacological action
- Unknown
- General Function
- Host cell surface binding
- Specific Function
- The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It...
- Gene Name
- ctxB
- Uniprot ID
- P01556
- Uniprot Name
- Cholera enterotoxin subunit B
- Molecular Weight
- 13957.055 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a...
- Gene Name
- KRTAP5-3
- Uniprot ID
- Q6L8H2
- Uniprot Name
- Keratin-associated protein 5-3
- Molecular Weight
- 22105.295 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Rhodobacter sphaeroides
- Pharmacological action
- Unknown
- General Function
- Trimethylamine-n-oxide reductase (cytochrome c) activity
- Specific Function
- Catalyzes the reduction of dimethyl sulfoxide (DMSO) and trimethylamine N-oxide (TMAO) to dimethyl sulfide (DMS) and trimethylamine, respectively. The terminal DMSO reductase can also use various s...
- Gene Name
- dmsA
- Uniprot ID
- Q57366
- Uniprot Name
- Dimethyl sulfoxide/trimethylamine N-oxide reductase
- Molecular Weight
- 89206.805 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Clostridium sp. (strain F1)
- Pharmacological action
- Unknown
- General Function
- Cellulase activity
- Specific Function
- This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
- Gene Name
- celC307
- Uniprot ID
- P23340
- Uniprot Name
- Endoglucanase C307
- Molecular Weight
- 40905.03 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Alpha-amylase activity
- Gene Name
- AMY2B
- Uniprot ID
- P19961
- Uniprot Name
- Alpha-amylase 2B
- Molecular Weight
- 57709.49 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Clostridium cellulovorans
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- engF
- Uniprot ID
- P94622
- Uniprot Name
- Endo-1,4-beta glucanase EngF
- Molecular Weight
- 60130.5 Da
- Kind
- Protein
- Organism
- Thermoactinomyces vulgaris
- Pharmacological action
- Unknown
- General Function
- Neopullulanase activity
- Specific Function
- Hydrolyzes pullulan efficiently but only a small amount of starch. Endohydrolysis of 1,4-alpha-glucosidic linkages in pullulan to form panose. Cleaves also (1-6)-alpha-glucosidic linkages to form m...
- Gene Name
- tvaII
- Uniprot ID
- Q08751
- Uniprot Name
- Neopullulanase 2
- Molecular Weight
- 67466.71 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Thermomonospora fusca
- Pharmacological action
- Unknown
- General Function
- Cellulose binding
- Specific Function
- Not Available
- Gene Name
- celD
- Uniprot ID
- P26221
- Uniprot Name
- Endoglucanase E-4
- Molecular Weight
- 95201.875 Da
- Kind
- Protein
- Organism
- Clostridium botulinum
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it ca...
- Gene Name
- botB
- Uniprot ID
- P10844
- Uniprot Name
- Botulinum neurotoxin type B
- Molecular Weight
- 150801.16 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Escherichia coli
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- stx2eB
- Uniprot ID
- Q47644
- Uniprot Name
- Orf protein
- Molecular Weight
- 9650.1 Da
- Kind
- Protein
- Organism
- Clostridium tetani (strain Massachusetts / E88)
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can ...
- Gene Name
- tetX
- Uniprot ID
- P04958
- Uniprot Name
- Tetanus toxin
- Molecular Weight
- 150680.98 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Streptomyces rubiginosus
- Pharmacological action
- Unknown
- General Function
- Xylose isomerase activity
- Specific Function
- Involved in D-xylose catabolism.
- Gene Name
- xylA
- Uniprot ID
- P24300
- Uniprot Name
- Xylose isomerase
- Molecular Weight
- 43226.915 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Bacillus sp. (strain 707)
- Pharmacological action
- Unknown
- General Function
- Glucan 1,4-alpha-maltohexaosidase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- P19571
- Uniprot Name
- Glucan 1,4-alpha-maltohexaosidase
- Molecular Weight
- 59008.445 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Pseudomonas stutzeri
- Pharmacological action
- Unknown
- General Function
- Starch binding
- Specific Function
- Not Available
- Gene Name
- amyP
- Uniprot ID
- P13507
- Uniprot Name
- Glucan 1,4-alpha-maltotetraohydrolase
- Molecular Weight
- 59875.725 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
- Pharmacological action
- Unknown
- General Function
- Cellulase activity
- Specific Function
- Probable endoglucanase involved in the degradation of cellulose or related beta-glucans.
- Gene Name
- celCCF
- Uniprot ID
- P37698
- Uniprot Name
- Endoglucanase F
- Molecular Weight
- 80543.885 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
- Pharmacological action
- Unknown
- General Function
- Glucose-fructose oxidoreductase activity
- Specific Function
- Not Available
- Gene Name
- gfo
- Uniprot ID
- Q07982
- Uniprot Name
- Glucose--fructose oxidoreductase
- Molecular Weight
- 47189.15 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Enterobacteria phage P22
- Pharmacological action
- Unknown
- General Function
- Hydrolase activity, acting on glycosyl bonds
- Specific Function
- Structural component of the short non-contractile tail. The tail comprises six fibers that mediate primary attachment to the host cell lipopolysaccharides (LPS) and display endorhamnosidase enzymat...
- Gene Name
- 9
- Uniprot ID
- P12528
- Uniprot Name
- Tail fiber protein
- Molecular Weight
- 71856.28 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Vitamin binding
- Specific Function
- Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known ...
- Gene Name
- PYGL
- Uniprot ID
- P06737
- Uniprot Name
- Glycogen phosphorylase, liver form
- Molecular Weight
- 97147.82 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Carbohydrate binding
- Specific Function
- Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and m...
- Gene Name
- SFTPD
- Uniprot ID
- P35247
- Uniprot Name
- Pulmonary surfactant-associated protein D
- Molecular Weight
- 37728.19 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Type i interferon receptor binding
- Specific Function
- Has antiviral, antibacterial and anticancer activities.
- Gene Name
- IFNB1
- Uniprot ID
- P01574
- Uniprot Name
- Interferon beta
- Molecular Weight
- 22293.68 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Transporter activity
- Specific Function
- Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
- Gene Name
- malE
- Uniprot ID
- P0AEX9
- Uniprot Name
- Maltose-binding periplasmic protein
- Molecular Weight
- 43387.235 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Identical protein binding
- Specific Function
- Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used i...
- Gene Name
- fabI
- Uniprot ID
- P0AEK4
- Uniprot Name
- Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
- Molecular Weight
- 27863.645 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Clostridium thermocellum
- Pharmacological action
- Unknown
- General Function
- Cellulase activity
- Specific Function
- This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
- Gene Name
- celA
- Uniprot ID
- P0C2S2
- Uniprot Name
- Endoglucanase A
- Molecular Weight
- 1449.625 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Chloride ion binding
- Specific Function
- Not Available
- Gene Name
- AMY2A
- Uniprot ID
- P04746
- Uniprot Name
- Pancreatic alpha-amylase
- Molecular Weight
- 57706.51 Da
References
- Zajoncova L, Jilek M, Beranova V, Pec P: A biosensor for the determination of amylase activity. Biosens Bioelectron. 2004 Sep 15;20(2):240-5. doi: 10.1016/j.bios.2004.01.006. [PubMed:15308227]
- Pierzynowski SG, Goncharova K, Gregory PC, Westrom B, Podpryatov SE, Podpriatov SS, Wolinski J, Repich H, Wierup N, Lozinska L: Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model. Sci Rep. 2017 Aug 17;7(1):8628. doi: 10.1038/s41598-017-07387-2. [PubMed:28819193]
- Date K, Satoh A, Iida K, Ogawa H: Pancreatic alpha-Amylase Controls Glucose Assimilation by Duodenal Retrieval through N-Glycan-specific Binding, Endocytosis, and Degradation. J Biol Chem. 2015 Jul 10;290(28):17439-50. doi: 10.1074/jbc.M114.594937. Epub 2015 May 28. [PubMed:26023238]
Drug created on June 13, 2005 13:24 / Updated on July 02, 2020 13:15