Dihydrofolate reductase

BE0001302ProteinYeastDFR1

Key enzyme in folate metabolism. It is acted on by 7 drugs in DrugBank.

Gene name
DFR1
UniProtKB entry
P22906Swiss-Prot
Residues / weight
192 residues · 22,138 Da
Also known as
1.5.1.3

Resolves to

Protein
UniProtP22906UniProt nameDYR_CANAX
Gene
GenBank563852
Structure
PDB1AI9PDB1AOEPDB1IA1
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dihydrofolate reductase, and which indications are they being tested in?

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