Trehalose-6-phosphate synthase

BE0001334ProteinEscherichia coli (strain K12)otsA

Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. It is acted on by 5 drugs in DrugBank.

Gene name
otsA
UniProtKB entry
P31677Swiss-Prot
Residues / weight
474 residues · 53,611 Da
Also known as
2.4.1.15 · Alpha,alpha-trehalose-phosphate synthase [UDP-forming] · Osmoregulatory trehalose synthesis protein A · OtsA · TPS

Resolves to

Protein
UniProtP31677UniProt nameOTSA_ECOLI
Gene
NCBI Gene946405GenBank577561
Pharmacology
KEGGecj:JW5312
Structure
PDB1GZ5PDB1UQTPDB1UQU
Drugs

What you can answer from here — as of May 03, 2025

5DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Trehalose-6-phosphate synthase, and which indications are they being tested in?

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