Lethal factor

BE0001363ProteinBacillus anthracislef

Lethal factor (LF), which constitutes one of the three proteins composing the anthrax toxin, is able to trigger rapid cell death in macrophages (PubMed:10475971, PubMed:11104681, PubMed:3711080, PubMed:8380282, PubMed:9563949, PubMed:9703991). It is acted on by 9 drugs in DrugBank.

Gene name
lef
UniProtKB entry
P15917Swiss-Prot
Cellular location
Secreted
Residues / weight
809 residues · 93,770 Da
Also known as
3.4.24.83 · Anthrax lethal toxin endopeptidase component · LF

Resolves to

Protein
UniProtP15917UniProt nameLEF_BACAN
Gene
NCBI Gene3361711GenBank143144
Pharmacology
KEGGbar:GBAA_pXO1_0172
Structure
PDB1J7NPDB1JKYPDB1PWP
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Lethal factor, and which indications are they being tested in?

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