Iron(3+)-hydroxamate-binding protein FhuD

BE0001379ProteinEscherichia coli (strain K12)fhuD

Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. It is acted on by 5 drugs in DrugBank.

Gene name
fhuD
UniProtKB entry
P07822Swiss-Prot
Cellular location
Periplasm
Residues / weight
296 residues · 32,998 Da
Also known as
Ferric hydroxamate uptake protein D · Ferrichrome-binding periplasmic protein · Iron(III)-hydroxamate-binding protein FhuD

Resolves to

Protein
UniProtP07822UniProt nameFHUD_ECOLI
Gene
NCBI Gene947510GenBank41440
Pharmacology
KEGGecj:JW0148
Structure
PDB1EFDPDB1ESZPDB1K2V
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Iron(3+)-hydroxamate-binding protein FhuD, how selective are they, and which programs against it are still in active trials?

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