Ferric citrate is a phosphate binder used to control serum phosphorus levels or as an iron supplement. Tetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease.
- Mechanism
- Curator reviewed · 10 references
Ferric (Fe3+) iron is absorbed from the gastrointestinal tract by divalent metal transporter-1, and reduced to ferrous (Fe2+) iron by ferrireductase and cytochrome b reductase 1. Ferrous iron is stored intracellularly in ferritin and transported into the blood by ferroportin 1. Transport by ferroportin 1 is coupled with oxidation to ferric iron by hephaestin or ceruloplasmin. Ferric iron in plasma is bound to transferrin, which carries iron to other cells. Iron is transported to mitochondria for the synthesis of heme or iron-sulfur clusters, which are integral parts of several metalloproteins like hemoglobin.
Ferric iron can also bind to phosphate in the gastrointestinal tract, which precipitates as the insoluble ferric phosphate. Ferric phosphate remains unabsorbed and is eliminated in the feces. Decreased phosphate absorption gradually lowers phosphate levels in the blood.
- Primary indication
- Tetraferric tricitrate decahydrate is indicated to control serum phosphorous in adults with chronic kidney disease who require dialysis.Curator reviewed · 2 structured indications
- Formula / weight
- C18H32Fe4O31 · 967.803 g/mol (avg)
- First approval
- Canada, 1988 · United States, 2014
- Also known as
- Ferric citrate hydrate
- Code names
- KRX-0502
- Brand names
Resolves to
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Which drugs share a target with Ferric citrate, and which of those have an active Phase 3 trial?
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