Alpha-ketoglutarate-dependent taurine dioxygenase

BE0001384ProteinEscherichia coli (strain K12)tauD

Catalyzes the alpha-ketoglutarate-dependent hydroxylation of taurine yielding sulfite and aminoacetaldehyde after decomposition of an unstable intermediate (PubMed:9287300). It is acted on by 1 drug in DrugBank.

Gene name
tauD
UniProtKB entry
P37610Swiss-Prot
Residues / weight
283 residues · 32,409 Da
Also known as
1.14.11.17 · 2-aminoethanesulfonate dioxygenase · SSI3 · ssiD · Sulfate starvation-induced protein 3

Resolves to

Protein
UniProtP37610UniProt nameTAUD_ECOLI
Gene
NCBI Gene945021GenBank1384060
Pharmacology
KEGGecj:JW0360
Structure
PDB1GQWPDB1GY9PDB1OS7
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-ketoglutarate-dependent taurine dioxygenase, how selective are they, and which programs against it are still in active trials?

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