Flavin-dependent thymidylate synthase

BE0001409ProteinThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)thyX

Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP or deoxyuridylate) to 2'-deoxythymidine-5'-monophosphate (dTMP or deoxythymidylate) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methylene donor, and NAD(P)H and FADH(2) as the reductant. It is acted on by 4 drugs in DrugBank.

Gene name
thyX
UniProtKB entry
Q9WYT0Swiss-Prot
Residues / weight
220 residues · 26,004 Da
Also known as
2.1.1.148 · FAD-dependent thymidylate synthase · FDTS · thy1 · Thymidylate synthase ThyX

Resolves to

Protein
UniProtQ9WYT0UniProt nameTHYX_THEMA
Gene
NCBI Gene897468GenBank4980954
Pharmacology
KEGGtma:TM0449
Structure
PDB1KQ4PDB1O24PDB1O25
Drugs

What you can answer from here — as of May 03, 2025

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Flavin-dependent thymidylate synthase, how selective are they, and which programs against it are still in active trials?

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