Metallo-beta-lactamase type 2

BE0001426ProteinBacillus cereusblm

Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. It is acted on by 5 drugs in DrugBank.

Gene name
blm
UniProtKB entry
P04190Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
257 residues · 28,092 Da
Also known as
3.5.2.6 · B2 metallo-beta-lactamase · Beta-lactamase 2 · Beta-lactamase II · Cephalosporinase

Resolves to

Protein
UniProtP04190UniProt nameBLA2_BACCE
Gene
GenBank142604
Structure
PDB1BC2PDB1BMCPDB1BVT
Drugs

What you can answer from here — as of May 03, 2025

5DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Metallo-beta-lactamase type 2, how selective are they, and which programs against it are still in active trials?

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