UDP-N-acetylhexosamine pyrophosphorylase

BE0001429ProteinHumansUAP1

Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). It is acted on by 2 drugs in DrugBank.

Gene name
UAP1
UniProtKB entry
Q16222Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
522 residues · 58,769 Da
Also known as
AGX · Antigen X · Protein-pyrophosphorylation enzyme · SPAG2 · Sperm-associated antigen 2

Resolves to

Protein
UniProtQ16222UniProt nameUAP1_HUMAN
Gene
HGNCHGNC:12457NCBI Gene6675GenBank7717462GeneCardsUAP1
Pharmacology
KEGGhsa:6675
Structure
PDB1JV1PDB1JV3PDB1JVD
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on UDP-N-acetylhexosamine pyrophosphorylase, and which indications are they being tested in?

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