Ganglioside GM2 activator

BE0001432ProteinHumansGM2A

Lipid-binding and transfer protein essential for lysosomal degradation of ganglioside GM2. It is acted on by 6 drugs in DrugBank.

Gene name
GM2A
UniProtKB entry
P17900Swiss-Prot
Cellular location
Lysosome
Residues / weight
193 residues · 20,838 Da
Also known as
Cerebroside sulfate activator protein · GM2-AP · SAP-3 · Sphingolipid activator protein 3

Resolves to

Protein
UniProtP17900UniProt nameSAP3_HUMAN
Gene
HGNCHGNC:4367NCBI Gene2760GenBank183357GeneCardsGM2A
Pharmacology
KEGGhsa:2760
Structure
PDB1G13PDB1PU5PDB1PUB
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
10GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
22+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Ganglioside GM2 activator, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In