Adenylosuccinate synthetase

BE0001441ProteinEscherichia coli (strain K12)purA

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. It is acted on by 9 drugs in DrugBank.

Gene name
purA
UniProtKB entry
P0A7D4Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
432 residues · 47,345 Da
Also known as
6.3.4.4 · adeK · AMPSase · IMP--aspartate ligase

Resolves to

Protein
UniProtP0A7D4UniProt namePURA_ECOLI
Gene
NCBI Gene948695GenBank147406
Pharmacology
KEGGecj:JW4135
Structure
PDB1ADEPDB1ADIPDB1CG0
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Adenylosuccinate synthetase, and which indications are they being tested in?

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