Formate dehydrogenase H

BE0001446ProteinEscherichia coli (strain K12)fdhF

Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors. It is acted on by 1 drug in DrugBank.

Gene name
fdhF
UniProtKB entry
P07658Swiss-Prot
Residues / weight
715 residues · 79,373 Da
Also known as
1.1.99.33 · 1.17.98.4 · FDH-H · Formate dehydrogenase-H subunit alpha · Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide

Resolves to

Protein
UniProtP07658UniProt nameFDHF_ECOLI
Gene
NCBI Gene948584GenBank14717816
Pharmacology
KEGGecj:JW4040
Structure
PDB1AA6PDB1FDIPDB1FDO
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Formate dehydrogenase H, and which indications are they being tested in?

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