Selenocysteine
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Identification
- Generic Name
- Selenocysteine
- DrugBank Accession Number
- DB02345
- Background
A naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and formate dehydrogenase contain the TGA codon, which codes for this amino acid. [PubChem]
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 168.05
Monoisotopic: 168.964200301 - Chemical Formula
- C3H7NO2Se
- Synonyms
- 3-selenyl-L-alanine
- L-selenocysteine
- Selenium cysteine
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UCathelicidin antimicrobial peptide Not Available Humans UNucleoside diphosphate kinase A Not Available Humans UFormate dehydrogenase H Not Available Escherichia coli (strain K12) UCysteine desulfurase Not Available Escherichia coli (strain K12) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
Pathway Category Selenoamino Acid Metabolism Metabolic - Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareEltrombopag The bioavailability of Selenocysteine can be decreased when combined with Eltrombopag. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Active Moieties
Name Kind UNII CAS InChI Key Selenium unknown H6241UJ22B 7782-49-2 BUGBHKTXTAQXES-UHFFFAOYSA-N - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Dialyvite 3000 Selenocysteine (70 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (15 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2004-02-01 Not applicable US Dialyvite 5000 Selenocysteine (70 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cobalamin (2 mg/1) + Folic acid (5 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (25 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2008-05-01 Not applicable US Dialyvite Supreme D Selenocysteine (70 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Cobalamin (1 mg/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (15 mg/1) + alpha-Tocopherol succinate (30 [iU]/1) Tablet, coated Oral Hillestad Pharmaceuticals Usa 2010-09-08 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Amino acids, peptides, and analogues
- Direct Parent
- L-alpha-amino acids
- Alternative Parents
- Amino acids / Monocarboxylic acids and derivatives / Carboxylic acids / Selenols / Organopnictogen compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Aliphatic acyclic compound / Amine / Amino acid / Carbonyl group / Carboxylic acid / Hydrocarbon derivative / L-alpha-amino acid / Monocarboxylic acid or derivatives / Organic nitrogen compound / Organic oxide
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- proteinogenic amino acid, L-alpha-amino acid, L-alanine derivative, selenocysteine (CHEBI:16633) / Other amino acids (C05688)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 0CH9049VIS
- CAS number
- 10236-58-5
- InChI Key
- ZKZBPNGNEQAJSX-REOHCLBHSA-N
- InChI
- InChI=1S/C3H7NO2Se/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1
- IUPAC Name
- (2R)-2-amino-3-selanylpropanoic acid
- SMILES
- N[C@@H](C[SeH])C(O)=O
References
- General References
- Zinoni F, Birkmann A, Stadtman TC, Bock A: Nucleotide sequence and expression of the selenocysteine-containing polypeptide of formate dehydrogenase (formate-hydrogen-lyase-linked) from Escherichia coli. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4650-4. [Article]
- External Links
- Human Metabolome Database
- HMDB0003288
- KEGG Compound
- C05688
- PubChem Compound
- 6326983
- PubChem Substance
- 46508133
- ChemSpider
- 23436
- 1549332
- ChEBI
- 16633
- ChEMBL
- CHEMBL109962
- PDBe Ligand
- SEC
- Wikipedia
- Selenocysteine
- PDB Entries
- 1aa6 / 1cc1 / 1fdi / 1fdo / 1h0h / 1kmk / 1kqf / 1kqg / 1pae / 1pfp … show 71 more
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, coated Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 143-146 °C PhysProp water solubility 3.92E+005 mg/L (at 0 °C) STEPHEN,H & STEPHEN,T (1963) - Predicted Properties
Property Value Source Water Solubility 325.0 mg/mL ALOGPS logP -3.2 ALOGPS logP -4.1 Chemaxon logS 0.29 ALOGPS pKa (Strongest Acidic) 1.27 Chemaxon pKa (Strongest Basic) 8.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 63.32 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 33.45 m3·mol-1 Chemaxon Polarizability 10.67 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9454 Blood Brain Barrier + 0.5652 Caco-2 permeable - 0.7223 P-glycoprotein substrate Non-substrate 0.7899 P-glycoprotein inhibitor I Non-inhibitor 0.9841 P-glycoprotein inhibitor II Non-inhibitor 0.9834 Renal organic cation transporter Non-inhibitor 0.9391 CYP450 2C9 substrate Non-substrate 0.8503 CYP450 2D6 substrate Non-substrate 0.815 CYP450 3A4 substrate Non-substrate 0.817 CYP450 1A2 substrate Non-inhibitor 0.938 CYP450 2C9 inhibitor Non-inhibitor 0.9535 CYP450 2D6 inhibitor Non-inhibitor 0.9623 CYP450 2C19 inhibitor Non-inhibitor 0.959 CYP450 3A4 inhibitor Non-inhibitor 0.9549 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9919 Ames test AMES toxic 0.6345 Carcinogenicity Non-carcinogens 0.7841 Biodegradation Ready biodegradable 0.941 Rat acute toxicity 1.5769 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9863 hERG inhibition (predictor II) Non-inhibitor 0.9697
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 115.8600975 predictedDarkChem Lite v0.1.0 [M-H]- 115.8765975 predictedDarkChem Lite v0.1.0 [M-H]- 118.292015 predictedDeepCCS 1.0 (2019) [M+H]+ 116.7027975 predictedDarkChem Lite v0.1.0 [M+H]+ 116.6927975 predictedDarkChem Lite v0.1.0 [M+H]+ 121.9776 predictedDeepCCS 1.0 (2019) [M+Na]+ 116.0280975 predictedDarkChem Lite v0.1.0 [M+Na]+ 116.0142975 predictedDarkChem Lite v0.1.0 [M+Na]+ 130.71857 predictedDeepCCS 1.0 (2019)
Targets
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1. DetailsCathelicidin antimicrobial peptide
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Antimicrobial protein that is an integral component of the innate immune system (PubMed:14978112, PubMed:16637646, PubMed:18818205, PubMed:22879591, PubMed:9736536). Binds to bacterial lipopolysaccharides (LPS) (PubMed:16637646, PubMed:18818205). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (PubMed:14978112). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro) (PubMed:9736536)
- Specific Function
- lipopolysaccharide binding
- Gene Name
- CAMP
- Uniprot ID
- P49913
- Uniprot Name
- Cathelicidin antimicrobial peptide
- Molecular Weight
- 19301.175 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
2. DetailsNucleoside diphosphate kinase A
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair
- Specific Function
- 3'-5' exonuclease activity
- Gene Name
- NME1
- Uniprot ID
- P15531
- Uniprot Name
- Nucleoside diphosphate kinase A
- Molecular Weight
- 17148.635 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
3. DetailsFormate dehydrogenase H
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors.
- Specific Function
- 4 iron, 4 sulfur cluster binding
- Gene Name
- fdhF
- Uniprot ID
- P07658
- Uniprot Name
- Formate dehydrogenase H
- Molecular Weight
- 79373.25 Da
References
4. DetailsCysteine desulfurase
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo. Can also desulfinate L-cysteine sulfinate (3-sulfino-L-alanine).
- Specific Function
- cysteine desulfurase activity
- Gene Name
- sufS
- Uniprot ID
- P77444
- Uniprot Name
- Cysteine desulfurase
- Molecular Weight
- 44433.435 Da
References
Drug created at June 13, 2005 13:24 / Updated at July 02, 2020 13:15