Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

BE0001447ProteinHumansPPP1CC

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). It is acted on by 4 drugs in DrugBank.

Gene name
PPP1CC
UniProtKB entry
P36873Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
323 residues · 36,983 Da
Also known as
3.1.3.16 · PP-1G · Protein phosphatase 1C catalytic subunit

Resolves to

Protein
UniProtP36873UniProt namePP1G_HUMAN
Gene
HGNCHGNC:9283NCBI Gene5501GenBank402778GeneCardsPPP1CC
Pharmacology
KEGGhsa:5501
Structure
PDB1IT6PDB1JK7PDB1U32
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, how selective are they, and which programs against it are still in active trials?

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