Dihydroorotase

BE0001452ProteinEscherichia coli (strain K12)pyrC

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. It is acted on by 4 drugs in DrugBank.

Gene name
pyrC
UniProtKB entry
P05020Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
348 residues · 38,827 Da
Also known as
3.5.2.3 · DHOase

Resolves to

Protein
UniProtP05020UniProt namePYRC_ECOLI
Gene
NCBI Gene945787GenBank42607
Pharmacology
KEGGecj:JW1049
Structure
PDB1J79PDB1XGEPDB2E25
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dihydroorotase, and which indications are they being tested in?

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