Vitamin B12 transporter BtuB

BE0001470ProteinEscherichia coli (strain K12)btuB

Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space (PubMed:4579869). It is acted on by 4 drugs in DrugBank.

Gene name
btuB
UniProtKB entry
P06129Swiss-Prot
Cellular location
Cell outer membrane
Residues / weight
614 residues · 68,407 Da
Also known as
bfe · cer · Cobalamin receptor · dcrC · Outer membrane cobalamin translocator

Resolves to

Protein
UniProtP06129UniProt nameBTUB_ECOLI
Gene
NCBI Gene948468GenBank145440
Pharmacology
KEGGecj:JW3938
Structure
PDB1NQEPDB1NQFPDB1NQG
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Vitamin B12 transporter BtuB, how selective are they, and which programs against it are still in active trials?

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