Cobalamin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Cobalamin
Accession Number
DB14098
Description
Not Available
Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 1329.37
Monoisotopic: 1328.564326
Chemical Formula
C62H88CoN13O14P
Synonyms
Not Available

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Product Images
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Biopar delta-FORTECobalamin (50 ug/1) + Cobamamide (50 ug/1) + Dihydrofolic Acid (1 mg/1) + Gastric intrinsic factor (50 mg/1) + Levoleucovorin (2.5 mg/1) + Levomefolate magnesium (7 mg/1)CapsuleOralJaymac Pharmacueticals LLC2020-09-01Not applicableUS flag
DialyviteCobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)Tablet, coatedOralAtlantic Biologicals Corps.1988-08-01Not applicableUS flag
DialyviteCobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)Tablet, coatedOralHillestad Pharmaceuticals Usa1988-08-01Not applicableUS flag
DialyviteCobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)Tablet, coatedOralCarilion Materials Management1988-08-01Not applicableUS flag
Dialyvite 3000Cobalamin (1 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (15 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2004-02-01Not applicableUS flag
Dialyvite 5000Cobalamin (2 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (5 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (25 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2008-05-01Not applicableUS flag
Dialyvite Supreme DCobalamin (1 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (15 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2010-09-08Not applicableUS flag
Dialyvite with ZincCobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (50 mg/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2002-10-01Not applicableUS flag10542 01220180618 22549 l4id3e
NephPlex RxCobalamin (.006 mg/1) + Ascorbic acid (60 mg/1) + Biotin (.3 mg/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Pantothenic acid (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine chloride (1.5 mg/1) + Zinc oxide (12.5 mg/1)Tablet, coatedOralNephro-Tech, Inc.1995-07-01Not applicableUS flag
Nephron FACobalamin (.006 mg/1) + Ascorbic acid (40 mg/1) + Biotin (.3 mg/1) + Folic acid (1 mg/1) + Iron (66 mg/1) + Nicotinamide (20 mg/1) + Pantothenic acid (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine chloride (1.5 mg/1)Tablet, coatedOralCarilion Materials Management1992-11-01Not applicableUS flag

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
8406EY2OQA
CAS number
13408-78-1
InChI Key
ASARMUCNOOHMLO-WLORSUFZSA-L
InChI
InChI=1S/C62H90N13O14P.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);/q;+2/p-2/t31-,34+,35+,36+,37-,41+,52+,53+,56+,57-,59+,60-,61-,62-;/m0./s1
IUPAC Name
lambda2-cobalt(2+) (1R,2R,3S,4S,6Z,8S,9S,11Z,14S,16Z,18R,19R)-4,9,14-tris(2-carbamoylethyl)-3,8,19-tris(carbamoylmethyl)-18-(2-{[(2S)-2-{[(2R,3S,4R,5S)-5-(5,6-dimethyl-1H-1,3-benzodiazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl phosphono]oxy}propyl]carbamoyl}ethyl)-2,3,6,8,13,13,16,18-octamethyl-20,21,22,23-tetraazapentacyclo[15.2.1.1^{2,5}.1^{7,10}.1^{12,15}]tricosa-5(23),6,10(22),11,15(21),16-hexaen-20-ide
SMILES
[Co++].[H]N([H])C(=O)CC[[email protected]@H]1C2=N\C(=C(C)/C3=N[[email protected]@](C)([[email protected]]4([H])[N-]\C(=C(C)/C5=N/C(=C\2)/C(C)(C)[[email protected]@H]5CCC(=O)N([H])[H])[[email protected]](C)(CCC(=O)N([H])C[[email protected]](C)OP([O-])(=O)O[[email protected]@H]2[[email protected]@H](CO)O[[email protected]@H]([[email protected]@H]2O)N2C=NC5=C2C=C(C)C(C)=C5)[[email protected]]4CC(=O)N([H])[H])[[email protected]@](C)(CC(=O)N([H])[H])[[email protected]@H]3CCC(=O)N([H])[H])\[[email protected]@]1(C)CC(=O)N([H])[H]

References

General References
Not Available
ChemSpider
34987587
RxNav
42604
Wikipedia
Cobalamin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentDiabetic Neuropathies / Polyneuropathies1
2CompletedTreatmentLung Cancers / Neoplasms Metastasis / Non-Small Cell Lung Carcinoma (NSCLC)1
2CompletedTreatmentVitamin B12 Deficiency1
2, 3RecruitingTreatmentDrug Induced Movement Disorder, Unspecified / Oxidative Stress / Schizophrenia1
Not AvailableCompletedBasic ScienceVitamin B 12 Deficiency1
Not AvailableCompletedTreatmentHealthy Volunteers1
Not AvailableCompletedTreatmentVitamin B 12 Deficiency1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral
TabletOral
Tablet, chewableOral
Tablet, coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0127 mg/mLALOGPS
logP2.63ALOGPS
logP-2.7ChemAxon
logS-5ALOGPS
pKa (Strongest Acidic)1.82ChemAxon
pKa (Strongest Basic)8.97ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count17ChemAxon
Hydrogen Donor Count9ChemAxon
Polar Surface Area460.05 Å2ChemAxon
Rotatable Bond Count26ChemAxon
Refractivity330.72 m3·mol-1ChemAxon
Polarizability132.57 Å3ChemAxon
Number of Rings8ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on June 18, 2018 12:53 / Updated on June 12, 2020 10:53

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