Cobalamin

Identification

Generic Name

Cobalamin

DrugBank Accession Number

DB14098

Background

Not Available

Type

Small Molecule

Groups

Experimental

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Cobalamin (DB14098)

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Weight

Average: 1329.37
Monoisotopic: 1328.564326

Chemical Formula

C₆₂H₈₈CoN₁₃O₁₄P

Synonyms

Not Available

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Ranitidine	Ranitidine can cause a decrease in the absorption of Cobalamin resulting in a reduced serum concentration and potentially a decrease in efficacy.

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Food Interactions

Not Available

Products

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Product Images

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Biopar delta-FORTE	Cobalamin (50 ug/1) + Cobamamide (50 ug/1) + Dihydrofolic Acid (1 mg/1) + Gastric intrinsic factor (50 mg/1) + Levoleucovorin (2.5 mg/1) + Levomefolate magnesium (7 mg/1)	Capsule	Oral	Jaymac Pharma	2023-06-01	Not applicable
Dialyvite	Cobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)	Tablet, coated	Oral	Hillestad Pharmaceuticals Usa	1988-08-01	Not applicable
Dialyvite	Cobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)	Tablet, coated	Oral	Carilion Materials Management	1988-08-01	Not applicable
Dialyvite	Cobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)	Tablet, coated	Oral	Atlantic Biologicals Corps.	1988-08-01	Not applicable
Dialyvite 3000	Cobalamin (1 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (15 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)	Tablet, coated	Oral	Hillestad Pharmaceuticals Usa	2004-02-01	Not applicable
Dialyvite 5000	Cobalamin (2 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (5 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (25 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)	Tablet, coated	Oral	Hillestad Pharmaceuticals Usa	2008-05-01	Not applicable
Dialyvite Supreme D	Cobalamin (1 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (15 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)	Tablet, coated	Oral	Hillestad Pharmaceuticals Usa	2010-09-08	Not applicable
Dialyvite with Zinc	Cobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (50 mg/1)	Tablet, coated	Oral	Hillestad Pharmaceuticals Usa	2002-10-01	Not applicable
NephPlex Rx	Cobalamin (.006 mg/1) + Ascorbic acid (60 mg/1) + Biotin (.3 mg/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Pantothenic acid (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine chloride (1.5 mg/1) + Zinc oxide (12.5 mg/1)	Tablet, coated	Oral	Nephro-Tech, Inc.	1995-07-01	Not applicable
Nephron FA	Cobalamin (.006 mg/1) + Ascorbic acid (40 mg/1) + Biotin (.3 mg/1) + Folic acid (1 mg/1) + Iron (66 mg/1) + Nicotinamide (20 mg/1) + Pantothenic acid (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine chloride (1.5 mg/1)	Tablet, coated	Oral	Nephro-Tech, Inc.	1992-11-01	Not applicable

Categories

Drug Categories

• Corrinoids
• Heterocyclic Compounds, Fused-Ring
• Micronutrients
• Vitamin B 12, biosynthesis
• Vitamin B Complex
• Vitamins

Classification

Not classified

Affected organisms

Not Available

Chemical Identifiers

UNII

8406EY2OQA

CAS number

13408-78-1

InChI Key

ASARMUCNOOHMLO-WLORSUFZSA-L

InChI

InChI=1S/C62H90N13O14P.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);/q;+2/p-2/t31-,34+,35+,36+,37-,41+,52+,53+,56+,57-,59+,60-,61-,62-;/m0./s1

IUPAC Name

lambda2-cobalt(2+) (1R,2R,3S,4S,6Z,8S,9S,11Z,14S,16Z,18R,19R)-4,9,14-tris(2-carbamoylethyl)-3,8,19-tris(carbamoylmethyl)-18-(2-{[(2S)-2-{[(2R,3S,4R,5S)-5-(5,6-dimethyl-1H-1,3-benzodiazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl phosphono]oxy}propyl]carbamoyl}ethyl)-2,3,6,8,13,13,16,18-octamethyl-20,21,22,23-tetraazapentacyclo[15.2.1.1^{2,5}.1^{7,10}.1^{12,15}]tricosa-5(23),6,10(22),11,15(21),16-hexaen-20-ide

SMILES

[Co++].[H]N([H])C(=O)CC[C@@H]1C2=N\C(=C(C)/C3=N[C@@](C)([C@]4([H])[N-]\C(=C(C)/C5=N/C(=C\2)/C(C)(C)[C@@H]5CCC(=O)N([H])[H])[C@](C)(CCC(=O)N([H])C[C@H](C)OP([O-])(=O)O[C@@H]2[C@@H](CO)O[C@@H]([C@@H]2O)N2C=NC5=C2C=C(C)C(C)=C5)[C@H]4CC(=O)N([H])[H])[C@@](C)(CC(=O)N([H])[H])[C@@H]3CCC(=O)N([H])[H])\[C@@]1(C)CC(=O)N([H])[H]

References

General References

Not Available

External Links

ChemSpider

34987587

Wikipedia

Cobalamin

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Recruiting	Treatment	Anemia / Tumor	1
3	Completed	Treatment	Diabetic Neuropathies / Polyneuropathies	1
2	Completed	Treatment	Lung Cancer / Metastatic Cancer / Non-Small Cell Lung Cancer (NSCLC)	1
2	Completed	Treatment	Vitamin B12 Deficiency	1
2, 3	Unknown Status	Treatment	Drug Induced Movement Disorder, Unspecified / Schizophrenia / Stress Oxidative	1
Not Available	Completed	Basic Science	Vitamin B12 Deficiency	1
Not Available	Completed	Treatment	Healthy Subjects (HS)	1
Not Available	Completed	Treatment	Vitamin B12 Deficiency	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Capsule	Oral
Tablet	Oral
Tablet, chewable	Oral
Capsule; kit; tablet, coated	Oral
Tablet, coated	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.0127 mg/mL	ALOGPS
logP	2.63	ALOGPS
logP	-2.7	Chemaxon
logS	-5	ALOGPS
pKa (Strongest Acidic)	1.82	Chemaxon
pKa (Strongest Basic)	8.97	Chemaxon
Physiological Charge	2	Chemaxon
Hydrogen Acceptor Count	17	Chemaxon
Hydrogen Donor Count	9	Chemaxon
Polar Surface Area	460.05 Å2	Chemaxon
Rotatable Bond Count	26	Chemaxon
Refractivity	330.72 m3·mol-1	Chemaxon
Polarizability	132.57 Å3	Chemaxon
Number of Rings	8	Chemaxon
Bioavailability	0	Chemaxon
Rule of Five	No	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	Yes	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

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Drug created at June 18, 2018 18:53 / Updated at June 12, 2020 16:53