Adenosine 5'-monophosphoramidase HINT1

BE0001473ProteinHumansHINT1

Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:15703176, PubMed:16835243, PubMed:17217311, PubMed:17337452, PubMed:22329685, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367). It is acted on by 6 drugs in DrugBank.

Gene name
HINT1
UniProtKB entry
P49773Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
126 residues · 13,802 Da
Also known as
3.9.1.- · Desumoylating isopeptidase HINT1 · HINT · Histidine triad nucleotide-binding protein 1 · PKCI-1

Resolves to

Protein
UniProtP49773UniProt nameHINT1_HUMAN
Gene
HGNCHGNC:4912NCBI Gene3094GenBank862933GeneCardsHINT1
Pharmacology
KEGGhsa:3094
Structure
PDB1AV5PDB1KPAPDB1KPB
Drugs

What you can answer from here — as of September 03, 2024

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenosine 5'-monophosphoramidase HINT1, how selective are they, and which programs against it are still in active trials?

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