Folylpolyglutamate synthase

BE0001492ProteinLactobacillus caseifpgS

Involved in the conversion of folates to polyglutamate derivatives, and likely functions in the retention of cellular folate pools. It is acted on by 4 drugs in DrugBank.

Gene name
fpgS
UniProtKB entry
P15925Swiss-Prot
Residues / weight
428 residues · 46,589 Da
Also known as
6.3.2.17 · Folylpoly-gamma-glutamate synthetase · FPGS · Tetrahydrofolate synthase · Tetrahydrofolylpolyglutamate synthase

Resolves to

Protein
UniProtP15925UniProt nameFPGS_LACCA
Gene
GenBank149542
Structure
PDB1FGSPDB1JBVPDB1JBW
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Folylpolyglutamate synthase, and which indications are they being tested in?

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