Cholera enterotoxin subunit B

BE0001496ProteinVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)ctxB

The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It is acted on by 14 drugs in DrugBank.

Gene name
ctxB
UniProtKB entry
P01556Swiss-Prot
Cellular location
Secreted
Residues / weight
124 residues · 13,957 Da
Also known as
Cholera enterotoxin B chain · Cholera enterotoxin gamma chain · Choleragenoid · toxB

Resolves to

Protein
UniProtP01556UniProt nameCHTB_VIBCH
Gene
NCBI Gene2613962GenBank48348
Pharmacology
KEGGvch:VC1456
Structure
PDB1CHPPDB1CHQPDB1CT1
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cholera enterotoxin subunit B, and which indications are they being tested in?

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