Farnesyl diphosphate synthase

BE0001517ProteinEscherichia coli (strain K12)ispA

Farnesyl diphosphate synthase (Escherichia coli (strain K12)) is a protein target in DrugBank. It is acted on by 3 drugs in DrugBank.

Gene name
ispA
UniProtKB entry
P22939Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
299 residues · 32,159 Da
Also known as
(2E,6E)-farnesyl diphosphate synthase · 2.5.1.10 · FPP synthase · Geranyltranstransferase

Resolves to

Protein
UniProtP22939UniProt nameISPA_ECOLI
Gene
NCBI Gene945064GenBank216583
Pharmacology
KEGGecj:JW0411
Structure
PDB1RQIPDB1RQJ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Farnesyl diphosphate synthase, how selective are they, and which programs against it are still in active trials?

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