Dihydroorotate dehydrogenase (quinone)

BE0001525ProteinEscherichia coli (strain K12)pyrD

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. It is acted on by 3 drugs in DrugBank.

Gene name
pyrD
UniProtKB entry
P0A7E1Swiss-Prot
Cellular location
Cell membrane
Residues / weight
336 residues · 36,774 Da
Also known as
1.3.5.2 · DHOD · DHODase · DHOdehase · Dihydroorotate oxidase

Resolves to

Protein
UniProtP0A7E1UniProt namePYRD_ECOLI
Gene
NCBI Gene945556GenBank42609
Pharmacology
KEGGecj:JW0928
Structure
PDB1F76
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydroorotate dehydrogenase (quinone), how selective are they, and which programs against it are still in active trials?

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