Orotate phosphoribosyltransferase

BE0001533ProteinSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)pyrE

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). It is acted on by 3 drugs in DrugBank.

Gene name
pyrE
UniProtKB entry
P08870Swiss-Prot
Residues / weight
213 residues · 23,562 Da
Also known as
2.4.2.10 · OPRT

Resolves to

Protein
UniProtP08870UniProt namePYRE_SALTY
Gene
NCBI Gene1255257GenBank47812
Pharmacology
KEGGstm:STM3733
Structure
PDB1LH0PDB1OPRPDB1STO
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Orotate phosphoribosyltransferase, how selective are they, and which programs against it are still in active trials?

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