5-O-phosphono-alpha-D-ribofuranosyl diphosphate

DB01632ApprovedWithdrawnSmall molecule

The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.

Chemical structure of 5-O-phosphono-alpha-D-ribofuranosyl diphosphate
Formula / weight
C5H13O14P3 · 390.0696 g/mol (avg)
Also known as
Phosphoribosyl pyrophosphate · Phosphoribosylpyrophosphate · PRib-PP · PRPP

Resolves to

Compound
UNIIW5555R4ERGCAS13270-65-0ChEMBLCHEMBL1235437ChEBI17111PubChem7339KEGGC00119
Structure
InChIKeyPQGCEDQWHSBAJP-TXICZTDVSA-NSMILESO[C@H]1[C@@H](O)[C@@H](OP(O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O
Targets
P20035LACZP00492HPRT1P08870pyrEQ9NWZ5UCKL1Q27796HGPRTaseP07741APRTQ8VP84trpD

What you can answer from here — as of September 23, 2026

7Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
7+ReferencesStructured and connected to the statements they support
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Which drugs share a target with 5-O-phosphono-alpha-D-ribofuranosyl diphosphate, and which of those have an active Phase 3 trial?

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