UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

BE0001538ProteinEscherichia coli (strain K12)murE

Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. It is acted on by 3 drugs in DrugBank.

Gene name
murE
UniProtKB entry
P22188Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
495 residues · 53,343 Da
Also known as
6.3.2.13 · Meso-A2pm-adding enzyme · Meso-diaminopimelate-adding enzyme · UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase · UDP-MurNAc-tripeptide synthetase

Resolves to

Protein
UniProtP22188UniProt nameMURE_ECOLI
Gene
NCBI Gene944791GenBank296014
Pharmacology
KEGGecj:JW0083
Structure
PDB1E8C
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
17+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In