p-hydroxybenzoate hydroxylase

BE0001543ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)pobA

Catalyzes the incorporation of an atom of dioxygen into p-hydroxybenzoate (p-OHB) to form 3,4-dihydroxybenzoate (3,4DOHB). It is acted on by 5 drugs in DrugBank.

Gene name
pobA
UniProtKB entry
P20586Swiss-Prot
Residues / weight
394 residues · 44,323 Da
Also known as
1.14.13.2 · 4-hydroxybenzoate 3-monooxygenase · PHBH

Resolves to

Protein
UniProtP20586UniProt namePHHY_PSEAE
Gene
NCBI Gene882128GenBank151506
Pharmacology
KEGGpae:PA0247
Structure
PDB1D7LPDB1DOBPDB1DOC
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on p-hydroxybenzoate hydroxylase, how selective are they, and which programs against it are still in active trials?

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