Cholesterol oxidase

BE0001550ProteinStreptomyces sp. (strain SA-COO)choA

Bifunctional enzyme that catalyzes the oxidation of the 3-beta-hydroxy group of cholesterol and the isomerization of the double bond of the resulting product, producing cholest-4-en-3-one. It is acted on by 2 drugs in DrugBank.

Gene name
choA
UniProtKB entry
P12676Swiss-Prot
Cellular location
Secreted
Residues / weight
546 residues · 58,993 Da
Also known as
1.1.3.6 · CHOD · Cholesterol isomerase

Resolves to

Protein
UniProtP12676UniProt nameCHOD_STRS0
Gene
GenBank153212
Structure
PDB1B4VPDB1B8SPDB1CBO
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cholesterol oxidase, how selective are they, and which programs against it are still in active trials?

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