Trypanothione reductase

BE0001551ProteinTrypanosoma cruziTPR

Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase. It is acted on by 5 drugs in DrugBank.

Gene name
TPR
UniProtKB entry
P28593Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
492 residues · 53,867 Da
Also known as
1.8.1.12 · N(1),N(8)-bis(glutathionyl)spermidine reductase · TR

Resolves to

Protein
UniProtP28593UniProt nameTYTR_TRYCR
Gene
GenBank162317
Structure
PDB1AOGPDB1BZLPDB1GXF
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Trypanothione reductase, how selective are they, and which programs against it are still in active trials?

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