Purine nucleoside phosphorylase 2

BE0001556ProteinEscherichia coli (strain K12)xapA

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. It is acted on by 2 drugs in DrugBank.

Gene name
xapA
UniProtKB entry
P45563Swiss-Prot
Residues / weight
277 residues · 29,834 Da
Also known as
2.4.2.1 · Inosine-guanosine phosphorylase · pndA · PNP II · Purine nucleoside phosphorylase II

Resolves to

Protein
UniProtP45563UniProt nameXAPA_ECOLI
Gene
NCBI Gene946878GenBank929584
Pharmacology
KEGGecj:JW2398
Structure
PDB1YQQPDB1YQUPDB1YR3
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Purine nucleoside phosphorylase 2, and which indications are they being tested in?

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