Glucosamine-6-phosphate deaminase 1

BE0001567ProteinHumansGNPDA1

Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. It is acted on by 3 drugs in DrugBank.

Gene name
GNPDA1
UniProtKB entry
P46926Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
289 residues · 32,668 Da
Also known as
3.5.99.6 · GlcN6P deaminase 1 · Glucosamine-6-phosphate isomerase 1 · GNPI · HLN

Resolves to

Protein
UniProtP46926UniProt nameGNPI1_HUMAN
Gene
HGNCHGNC:4417NCBI Gene10007GenBank2935438GeneCardsGNPDA1
Pharmacology
KEGGhsa:10007
Structure
PDB1NE7
Drugs

What you can answer from here — as of February 11, 2025

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Glucosamine-6-phosphate deaminase 1, and which indications are they being tested in?

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